Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12371643 | 0.86 | MEN1 (0.56) | CYP3A4CYP3A5MEN1KMT2AMAPT | |
| SCHEMBL13476476 | 0.86 | CYP3A4 (0.48) | CYP3A4CYP3A5MEN1KMT2AMAPT | |
| SCHEMBL5183732 | 0.83 | MEN1 (0.49) | CYP3A4CYP3A5MEN1KMT2AMAPT | |
| SCHEMBL4879724 | 0.83 | CYP3A4 (0.52) | CYP3A4CYP3A5MEN1KMT2AMAPT | |
| SCHEMBL19668491 | 0.82 | CYP3A4 (0.47) | CYP3A4CYP3A5MEN1KMT2AMAPT | |
| SCHEMBL29508239 | 0.82 | CYP3A4 (0.47) | CYP3A4CYP3A5MEN1KMT2AMAPT | |
| SCHEMBL14128435 | 0.80 | GPR119 (0.50) | CYP3A4CYP3A5MEN1KMT2AMAPT | |
| SCHEMBL13476475 | 0.80 | P2RX3 (0.48) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL29361106 | 0.80 | CFTR (0.46) | CYP3A4CYP3A5MAPTNPC1ALDH1A1 | |
| SCHEMBL19668532 | 0.80 | CFTR (0.46) | CYP3A4CYP3A5MAPTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234282-A1 | 2-(Arylalkoxy)-1-Phenylethylamine Derivatives As NK1 Antagonist And Serotonin Reuptake Inhibitors | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | US | disclosed |
| US-7368448-B2 | 2-(arylalkoxy)-1-phenylethylamine derivatives as NK1 antagonist and serotonin reuptake inhibitors | ASTRAZENECA AB (SE) | 2008-05-06 | — | — | US | disclosed |
| US-20070185127-A1 | 2-(Arylalkoxy)-1-phenylethylamine derivatives as nk1 antagonist and serotonin reuptake inhibitors | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
| EP-1740552-A1 | 2- ( ARYLALKOXY ) -1- PHENYLETHYLAMINE DERIVATIVES AS NK1 ANTAGONIST AND SEROTONIN REUPTAKE INHIBITORS | AstraZeneca AB (SE) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005100324-A1 | 2- ( ARYLALKOXY ) -1- PHENYLETHYLAMINE DERIVATIVES AS NK1 ANTAGONIST AND SEROTONIN REUPTAKE INHIBITORS | ASTRAZENECA AB (SE) | 2005-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185127-A1 | 2-(Arylalkoxy)-1-phenylethylamine derivatives as nk1 antagonist and serotonin reuptake inhibitors | HTR1A, TPH1, HTR2A | CYP3A4 1008/4885CYP3A5 696/4885MEN1 1612/4885 |
| US-20080234282-A1 | 2-(Arylalkoxy)-1-Phenylethylamine Derivatives As NK1 Antagonist And Serotonin Reuptake Inhibitors | HTR1A, HTR2A, TPH1 | CYP3A4 1329/4885CYP3A5 848/4885MEN1 1973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.