Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 1.00 |
| ▸ | GABRP | O00591 | 1/20 | 0.66 |
| ▸ | GABRD | O14764 | 1/20 | 0.66 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.66 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.66 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.66 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.66 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.66 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.66 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.66 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.66 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.66 |
| ▸ | GABRE | P78334 | 1/20 | 0.66 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.66 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.66 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.66 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL10867618 | 0.82 | HTR6 (0.70) | HTR6GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL6631651 | 0.81 | KDM4E (0.70) | HTR6GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL3836149 | 0.81 | HTR6 (0.67) | HTR6GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7460028 | 0.81 | HTR6 (0.67) | HTR6GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2778860 | 0.81 | HTR6 (0.67) | HTR6GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1675799 | 0.81 | HTR6 (0.67) | HTR6GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2783986 | 0.81 | HTR6 (0.67) | HTR6KDM4EALDH1A1MAPTHTR2C | |
| SCHEMBL7365177 | 0.81 | GABRP (1.00) | HTR6GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL6639190 | 0.80 | HTR6 (0.67) | HTR6GABRPGABRDGABRA1GABRB1 | |
| Ethylene SCHEMBL7483843 | 0.79 | HTR6 (0.65) | HTR6GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015082499-A2 | PHARMACEUTICAL COMPOUND | IOMET PHARMA LTD (GB) | 2015-06-11 | — | — | WO | disclosed |
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | BRAINCELLS, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | BRAINCELLS, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| EP-1945213-A2 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | disclosed |
| US-20080015214-A1 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-01-17 | — | — | US | disclosed |
| US-20080015214-A1 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-01-17 | — | — | US | disclosed |
| WO-2007050381-A2 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-05-03 | — | — | WO | disclosed |
| WO-2007050381-A2 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-05-03 | — | — | WO | disclosed |
| US-7041683-B2 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan | WYETH (US) | 2006-05-09 | — | — | US | disclosed |
| US-6987117-B2 | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine | WYETH (US) | 2006-01-17 | — | — | US | disclosed |
| WO-2002072587-A1 | ANTIDEPRESSANT AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO[2,3-F]QUINOLINE | WYETH (US) | 2002-09-19 | — | — | WO | disclosed |
| US-20020072611-A1 | Antipsychotic heterocycle compounds | BRISTOL-MYERS SQUIBB COMPANY | 2002-06-13 | — | — | US | disclosed |
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997047302-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5693655-A | 3-indolylpiperidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-02 | — | — | US | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020072611-A1 | Antipsychotic heterocycle compounds | HTR2C, DRD2, HTR1A | HTR6 23/4885GABRP 293/4885GABRD 473/4885 |
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | HTR6, GAP43, HTR5A | HTR6 1/4885GABRP 445/4885GABRD 598/4885 |
| US-20080015214-A1 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | OGFRL1, OPRL1, ORMDL3 | HTR6 139/4885GABRP 366/4885GABRD 769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.