Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.71 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.71 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.71 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.71 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ITK | Q08881 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL976938 | 0.89 | F2 (0.59) | CASP3SENP8SENP7SENP6KIF11 | |
| SCHEMBL5434147 | 0.86 | MAPT (0.57) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL28580125 | 0.84 | RAB9A (0.61) | CASP3SENP8SENP7SENP6KIF11 | |
| SCHEMBL3704691 | 0.83 | CASP3 (1.00) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL29941485 | 0.83 | CASP3 (1.00) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL21657928 | 0.82 | KIF11 (0.50) | CASP3SENP8SENP7SENP6KIF11 | |
| SCHEMBL22887217 | 0.82 | NPC1 (0.53) | CASP3SENP8SENP7SENP6KIF11 | |
| SCHEMBL5730440 | 0.81 | KDM4E (0.62) | CASP3SENP8SENP7SENP6KIF11 | |
| SCHEMBL30344399 | 0.81 | CASP3 (0.77) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL5443742 | 0.81 | CASP3 (0.77) | CASP3SENP8SENP7SENP6CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039625-A1 | Screening Methods | LAUTENS MARK | 2008-02-14 | — | — | US | disclosed |
| US-20080039625-A1 | Screening Methods | LAUTENS MARK | 2008-02-14 | — | — | US | disclosed |
| US-20080039625-A1 | Screening Methods | LAUTENS MARK | 2008-02-14 | — | — | US | disclosed |
| EP-1817283-A1 | 2-SUBSTITUTED INDOLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF | Lautens, Mark (CA) | 2007-08-15 | — | — | EP | disclosed |
| US-20070167447-A1 | Indole acetamides as inhibitors of the hepatitis c virus ns5b polymerase | ISTITUTO DI RICERCHE DI BIOLOGIA DI MOLECULOARE P. ANGELETTI SPA (IT) | 2007-07-19 | — | — | US | disclosed |
| US-20070072911-A1 | Indoles and azaindoles as antiviral agents | AVOLIO SALVATORE | 2007-03-29 | — | — | US | disclosed |
| EP-1673081-A1 | INDOLES AND AZAINDOLES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2006-06-28 | — | — | EP | disclosed |
| WO-2006047888-A1 | 2-SUBSTITUTED INDOLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF | LAUTENS MARK (CA) | 2006-05-11 | — | — | WO | disclosed |
| EP-1613634-A1 | INDOLE ACETAMIDES AS INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2006-01-11 | — | — | EP | disclosed |
| WO-2005034941-A1 | INDOLES AND AZAINDOLES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2005-04-21 | — | — | WO | disclosed |
| WO-2004087714-A1 | INDOLE ACETAMIDES AS INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039625-A1 | Screening Methods | CBR3, ZKSCAN2, CRBN | CASP3 3258/4885SENP8 4693/4885SENP7 4140/4885 |
| US-20070072911-A1 | Indoles and azaindoles as antiviral agents | IDO1, IDO2, NAT1 | CASP3 1343/4885SENP8 4535/4885SENP7 4377/4885 |
| US-20070167447-A1 | Indole acetamides as inhibitors of the hepatitis c virus ns5b polymerase | IDO1, NAT1, AANAT | CASP3 2355/4885SENP8 4254/4885SENP7 4385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.