Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 13/20 | 0.48 |
| ▸ | PYGM | P11217 | 13/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210505 | 0.86 | PYGL (0.44) | PYGLPYGMCYP2C9KDM4EMEN1 | |
| SCHEMBL7945527 | 0.85 | LMNA (0.47) | PYGLPYGMCYP2C9KDM4EMEN1 | |
| SCHEMBL9121989 | 0.84 | CYP2C9 (0.49) | PYGLPYGMCYP2C9KDM4EMEN1 | |
| SCHEMBL9032248 | 0.83 | CYP2C9 (0.51) | PYGLPYGMCYP2C9KDM4EMEN1 | |
| SCHEMBL4790038 | 0.82 | CYP2C9 (0.58) | PYGLPYGMCYP2C9KDM4EMEN1 | |
| SCHEMBL4881545 | 0.80 | LMNA (0.61) | PYGLPYGMCYP2C9KDM4EMEN1 | |
| SCHEMBL8511172 | 0.78 | CYP2C9 (0.45) | PYGLPYGMCYP2C9KDM4EMEN1 | |
| SCHEMBL9032779 | 0.78 | CYP2C9 (0.57) | PYGLPYGMCYP2C9KDM4EMEN1 | |
| SCHEMBL9804865 | 0.78 | CYP2C9 (0.57) | PYGLPYGMCYP2C9KDM4EMEN1 | |
| SCHEMBL8672503 | 0.78 | PYGL (0.48) | PYGLPYGMCYP2C9KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080095841-A1 | Pharmaceutical Composition, Method for Producing the Same, and Method for Stabilizing Dihydropyridine Compound in the Pharmaceutical Composition | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-04-24 | — | — | US | disclosed |
| EP-1813274-A1 | MEDICINAL COMPOSITION, PROCESS FOR PRODUCING THE SAME, AND METHOD OF STABILIZING DIHYDROPYRIDINE COMPOUND IN MEDICINAL COMPOSITION | Eisai R&D Management Co., Ltd. (JP) | 2007-08-01 | — | — | EP | disclosed |
| EP-0804229-B1 | USE OF AMLODIPINE, A SALT THEREOF OR FELODIPIN IN COMBINATION WITH AN ACE INHIBITOR IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF NONISCHEMIC CONGESTIVE HEART FAILURE | PFIZER (US) | 2003-03-26 | — | — | EP | disclosed |
| US-20020049155-A1 | Cobalamin compounds useful as cardiovascular agents and as imaging agents | HOGENKAMP HENRICUS P C (US) | 2002-04-25 | — | — | US | disclosed |
| US-5519012-A | CALCIUM ANTAGONISTS, CARDIOVASCULAR DISORDERS | LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, D.D., LJUBLJANA (SI) | 1996-05-21 | — | — | US | disclosed |
| EP-0566142-A1 | Inclusion complexes of optically active and racemic 1,4-dihydro pyridines with cyclodextrin derivates | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. (SI) | 1993-10-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049155-A1 | Cobalamin compounds useful as cardiovascular agents and as imaging agents | APOB, MMAB, CBS | PYGL 978/4885PYGM 720/4885CYP2C9 578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.