Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740494 | 0.74 | HTT (0.65) | HTTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL13800066 | 0.70 | HTT (0.59) | HTTMEN1KMT2AGAAHSP90AA1 | |
| SCHEMBL14571460 | 0.65 | KMT2A (0.80) | HTTMEN1KMT2AGAAHSP90AA1 | |
| SCHEMBL17643209 | 0.62 | MEN1 (0.80) | HTTMEN1KMT2AGAAHSP90AA1 | |
| SCHEMBL186246 | 0.62 | LMNA (0.52) | MEN1KMT2AGAAMAPTRECQL | |
| SCHEMBL3663307 | 0.62 | ABL1 (0.43) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL2681081 | 0.62 | GABRA2 (0.58) | KMT2AGAAMAPTCYP2C19KDM4E | |
| SCHEMBL27031267 | 0.62 | KDM4E (0.48) | HTTMEN1KMT2ARECQLKDM4E | |
| SCHEMBL17643227 | 0.61 | MEN1 (0.83) | HTTMEN1KMT2AGAAHSP90AA1 | |
| SCHEMBL4742652 | 0.61 | APLNR (0.54) | HTTMEN1KMT2AGAAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089051-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES: PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |