Water

Water

SCHEMBL4883963

O.O=C(O)c1ccc(O)c(O)c1O

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 known ✓ Q13547 1/20 0.52
MEN1 known ✓ O00255 2/20 0.48
KDR known ✓ P35968 2/20 0.48
PDE4A known ✓ P27815 1/20 0.48
PTGS2 known ✓ P35354 2/20 0.48
ALOX5 known ✓ P09917 1/20 0.48
PIK3CA known ✓ P42336 1/20 0.46
THRB known ✓ P10828 1/20 0.45
ESR2 known ✓ Q92731 1/20 0.45
SELL P14151 1/20 0.95
SELP P16109 1/20 0.95
KMT2A Q03164 2/20 0.48
BLVRB P30043 1/20 0.48
HTT P42858 1/20 0.48
ALDH1A1 P00352 5/20 0.48
CA1 P00915 4/20 0.48
CA2 P00918 4/20 0.48
CA12 O43570 3/20 0.48
CA7 P43166 3/20 0.48
CA9 Q16790 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL77708 0.97 SELL (1.00) SELLSELPHDAC1MEN1KDR
SCHEMBL31236653 0.97 SELL (1.00) SELLSELPHDAC1MEN1KDR
Hydrochloric Acid SCHEMBL23929227 0.95 SELL (0.95) SELLSELPHDAC1MEN1KDR
SCHEMBL27857128 0.95 SELL (0.95) SELLSELPHDAC1MEN1KDR
SCHEMBL176255 0.87 SELL (0.79) SELLSELPMEN1KDRKMT2A
SCHEMBL29860525 0.87 SELL (0.79) SELLSELPMEN1KDRKMT2A
SCHEMBL9328169 0.86 SELL (0.70) SELLSELPHDAC1MEN1KDR
Benzoic Acid SCHEMBL28717274 0.85 SELL (0.76) SELLSELPHDAC1KMT2AALDH1A1
SCHEMBL11043522 0.84 SELL (0.75) SELLSELPMEN1KDRKMT2A
SCHEMBL29250135 0.84 SELL (0.75) SELLSELPMEN1KDRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080054520-A1 gear which hardly peels off on a joined boundary face even where a polyamide resin-molded gear core is joined to a polyamide resin-molded gear tooth, and is excellent in dimensional accuracy. Forming a dispersion for coating the gear. KOJI TOMODA (JP) 2008-03-06 US disclosed
EP-0141481-B1 METHOD OF MAKING POLYIMIDE FOAM PRECURSOR Imi-Tech Corporation (US) 1989-03-22 EP disclosed