Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68487 | 0.82 | PTGS2 (0.58) | PTGS2PTGS1AKR1B1CXCL8GLO1 | |
| SCHEMBL11295545 | 0.75 | PTGS2 (0.56) | PTGS2PTGS1AKR1B1CXCL8GLO1 | |
| SCHEMBL2237110 | 0.72 | PTGS2 (0.61) | PTGS2PTGS1AKR1B1CXCL8GLO1 | |
| SCHEMBL3494614 | 0.71 | HDAC10 (0.40) | ALDH1A1HPGDHSD17B10KDM4EMAPT | |
| SCHEMBL11364366 | 0.69 | PTGS1 (0.46) | PTGS2PTGS1AKR1B1CXCL8GLO1 | |
| SCHEMBL2578761 | 0.69 | HIF1A (0.44) | PTGS2PTGS1TBXAS1ALDH1A1HSD17B10 | |
| SCHEMBL23881352 | 0.68 | TBXAS1 (0.48) | AKR1B1TBXAS1ALDH1A1KDM4EATM | |
| SCHEMBL31445978 | 0.68 | PTGS2 (0.46) | PTGS2PTGS1AKR1B1CXCL8GLO1 | |
| SCHEMBL11380056 | 0.68 | PTGS1 (0.45) | PTGS2PTGS1AKR1B1CXCL8GLO1 | |
| SCHEMBL2235453 | 0.68 | PTGS2 (0.56) | PTGS2PTGS1AKR1B1CXCL8GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015202-A1 | Thiazole Derivatives Having Vap-1 Inhibitory Activity | ASTELLAS PHARMA INC. (JP) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015202-A1 | Thiazole Derivatives Having Vap-1 Inhibitory Activity | VCAM1, VAPB, VAPA | PTGS2 3575/4885PTGS1 2306/4885AKR1B1 1664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.