Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.53 |
| ▸ | NTMT1 | Q9BV86 | 2/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | MC3R | P41968 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | NMT2 | O60551 | 4/20 | 0.43 |
| ▸ | NMT1 | P30419 | 4/20 | 0.43 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4886971 | 0.89 | CHRNB2 (0.52) | GRIN1GRIN2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL4884646 | 0.88 | NTMT1 (0.51) | GRIN1GRIN2ANTMT1PLGKLKB1 | |
| SCHEMBL4885602 | 0.84 | PLG (0.54) | GRIN1GRIN2APLGKLKB1CTSB | |
| SCHEMBL4887070 | 0.82 | PLG (0.55) | GRIN1GRIN2APLGKLKB1CTSB | |
| SCHEMBL4886967 | 0.81 | CHRNB2 (0.47) | GRIN1GRIN2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL14111122 | 0.81 | CHRNB2 (0.46) | GRIN1GRIN2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL14596253 | 0.81 | CHRNB2 (0.46) | GRIN1GRIN2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL4879315 | 0.79 | CPB2 (0.50) | GRIN1GRIN2APLGKLKB1 | |
| SCHEMBL4888144 | 0.79 | UTS2R (0.47) | BDKRB2 | |
| SCHEMBL4884654 | 0.77 | NTMT1 (0.50) | NTMT1PLGMC4RMC3RBDKRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080171783-A1 | COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE | MIGENIX INC. (CA) | 2008-07-17 | — | — | US | disclosed |
| US-20070021434-A1 | NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF | MIGENIX INC. (CA) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021434-A1 | NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF | HAVCR2, ADAR, NSUN2 | GRIN1 3488/4885GRIN2A 3906/4885CHRNB2 4867/4885 |
| US-20080171783-A1 | COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE | POLQ, POLI, POLH | GRIN1 4667/4885GRIN2A 4730/4885CHRNB2 4254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.