Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 3/20 | 0.49 |
| ▸ | FLT4 | P35916 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895201 | 0.92 | FLT1 (0.48) | MMP2MMP9MMP14ADAM17FLT1 | |
| SCHEMBL4897816 | 0.88 | EGFR (0.57) | MMP2MMP9MMP14ADAM17FLT1 | |
| SCHEMBL4893079 | 0.87 | MMP2 (0.52) | MMP2MMP9MMP14ADAM17FLT1 | |
| SCHEMBL4892139 | 0.80 | THRA (0.55) | MMP2MMP9MMP14ADAM17ESR1 | |
| SCHEMBL4887098 | 0.72 | THRA (0.69) | ESR1NR3C1PGRNR3C2AR | |
| SCHEMBL23909567 | 0.70 | FLT1 (0.85) | MMP2MMP9FLT1FLT4KDR | |
| SCHEMBL5742900 | 0.69 | CA2 (0.62) | MMP2MMP9FLT1FLT4KDR | |
| SCHEMBL8661710 | 0.69 | FLT1 (0.74) | MMP2MMP9FLT1FLT4KDR | |
| SCHEMBL5619812 | 0.69 | THRA (0.57) | THRATHRB | |
| SCHEMBL8654939 | 0.68 | FLT1 (0.76) | MMP2MMP9FLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005538-B1 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | KARO BIO AB (SE) | 2006-02-28 | — | — | US | claimed |
| US-20080027096-A1 | Novel Pharmaceutical Compositions | KARO BIO AB (SE) | 2008-01-31 | — | — | US | disclosed |
| US-7319163-B2 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | KARO BIO AB (SE) | 2008-01-15 | — | — | US | disclosed |
| EP-1729756-A2 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2006-12-13 | — | — | EP | disclosed |
| US-7005538-B1 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | KARO BIO AB (SE) | 2006-02-28 | — | — | US | disclosed |
| US-20050267206-A1 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | MALM JOHAN | 2005-12-01 | — | — | US | disclosed |
| WO-2005094810-A2 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2005-10-13 | — | — | WO | disclosed |
| WO-2001036365-A2 | THYROID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIAC AND METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267206-A1 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | TSHR, THRB, THRA | MMP2 4488/4885MMP9 4754/4885MMP14 4582/4885 |
| US-20080027096-A1 | Novel Pharmaceutical Compositions | AR, NR5A1, CYP17A1 | MMP2 2628/4885MMP9 2709/4885MMP14 2590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.