SCHEMBL488748

SCHEMBL488748

Fc1ccc(CBr)c(C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.59
SLC6A2 P23975 9/20 0.43
SLC6A4 P31645 9/20 0.43
SLC6A3 Q01959 1/20 0.43
HDAC3 O15379 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
DHFR P00374 1/20 0.40
P2RX7 Q99572 6/20 0.39
GPR183 P32249 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29616489 1.00 IDO1 (0.59) IDO1SLC6A2SLC6A4SLC6A3HDAC3
SCHEMBL75416 0.88 IDO1 (0.46) IDO1SLC6A2SLC6A4SLC6A3HDAC3
SCHEMBL28763543 0.84 IDO1 (0.56) IDO1SLC6A2SLC6A4SLC6A3HDAC3
SCHEMBL1538597 0.83 IDO1 (0.63) IDO1SLC6A2SLC6A4SLC6A3HDAC3
SCHEMBL3278241 0.81 IDO1 (0.61) IDO1SLC6A2SLC6A4SLC6A3HDAC3
SCHEMBL14774588 0.81 IDO1 (0.56) IDO1SLC6A2SLC6A4SLC6A3HDAC3
SCHEMBL17864241 0.79 IDO1 (0.59) IDO1SLC6A2SLC6A4SLC6A3HDAC3
SCHEMBL109671 0.79 IDO1 (0.65) IDO1SLC6A2SLC6A4SLC6A3HDAC3
SCHEMBL195156 0.79 KDM1A (0.43) IDO1SLC6A4GPR183
SCHEMBL8417818 0.79 IDO1 (0.59) IDO1SLC6A2SLC6A4SLC6A3HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 293 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260034123-A1 CDK2 INHIBITORS AND METHODS OF USING THE SAME CEDILLA THERAPEUTICS INC (US) 2026-02-05 US disclosed
US-20260007672-A1 INHIBITORS OF MPTP NRG THERAPEUTICS LTD (GB) 2026-01-08 US disclosed
US-12491185-B2 Inhibitors of mPTP NRG THERAPEUTICS LTD (GB) 2025-12-09 US disclosed
EP-4652162-A1 INHIBITORS OF MPTP NRG Therapeutics LTD (GB) 2025-11-26 EP disclosed
US-12331022-B2 Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors MERCK SHARP & DOHME LLC (US) 2025-06-17 US disclosed
US-20250177397-A1 INHIBITORS OF MPTP NRG THERAPEUTICS LTD (GB) 2025-06-05 US disclosed
EP-4562016-A2 CDK2 INHIBITORS AND METHODS OF USING THE SAME Cedilla Therapeutics, Inc. (US) 2025-06-04 EP disclosed
WO-2024153946-A1 INHIBITORS OF MPTP NRG THERAPEUTICS LTD (GB) 2024-07-25 WO disclosed
US-20240239775-A1 FXR REGULATOR, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF BEIJING BEST PATHWAY MANAGEMENT CONSULTING CENTER (LIMITED PARTNERSHIP) (CN) 2024-07-18 US disclosed
WO-2024095003-A1 NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY Cerevance, Inc. (US) 2024-05-10 WO disclosed
WO-2001081316-A2 SUBSTITUTED PHENYL FARNESYLTRANSFERASE INHIBITORS ABBOTT LABORATORIES (US) 2001-11-01 WO disclosed
EP-1140930-A1 DIBENZO a,g]QUINOLIZINIUM DERIVATIVES AND THE SALTS THEREOF HANWHA CHEMICAL CORPORATION (KR) 2001-10-10 EP disclosed
US-6150526-A Piperidine derivative having renin inhibiting activity HOFFMANN-LA ROCHE INC. (US) 2000-11-21 US disclosed
WO-2000037468-A1 DIBENZO[a,g]QUINOLIZINIUM DERIVATIVES AND THE SALTS THEREOF HANWHA CHEMICAL CORPORATION (KR) 2000-06-29 WO disclosed
US-6051712-A PREVENTION OF HIGH BLOOD PRESSURE AND CARDIAC INSUFFICIENCY, AS WELL AS GLAUCOMA, CARDIAC INFARCT, KIDNEY INSUFFICIENCY AND RESTENOSIS HOFFMANN-LA ROCHE INC. (US) 2000-04-18 US disclosed
US-6030979-A INHIBITS THE STEROL 14-REDUCTASE WHICH CATALYZES THE BIOSYNTHESIS OF CHOLESTEROL FROM LANOSTEROL; ANTICHOLESTEROL AND-LIPEMIC AGENTS HANWHA CORPORATION (CN) 2000-02-29 US disclosed
US-6028197-A ENZYME INHIBITORS INHIBITING THE STEROL 14-REDUCTASE WHICH IS INVOLVED IN THE DISTAL PATHWAY OF CHOLESTEROL BIOSYNTHESIS, AND THE USE AS ANTICHOLESTEROL AGENTS OR ANTILIPEMIC AGENTS HANWHA CORPORATION (KR) 2000-02-22 US disclosed
CN-1202152-A Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency HOFFMANN LA ROCHE (CH) 1998-12-16 CN disclosed
EP-0863875-A1 NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY F. HOFFMANN-LA ROCHE AG (CH) 1998-09-16 EP disclosed
WO-1997009311-A1 NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY F. HOFFMANN-LA ROCHE AG (CH) 1997-03-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12331022-B2 Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors CHRNA7, CHRNA5, CHRNA2 IDO1 1452/4885SLC6A2 371/4885SLC6A4 1062/4885
US-20260034123-A1 CDK2 INHIBITORS AND METHODS OF USING THE SAME CDK2, CDK1, CDK20 IDO1 2935/4885SLC6A2 3959/4885SLC6A4 4399/4885
US-12491185-B2 Inhibitors of mPTP PARK7, PINK1, SNCA IDO1 225/4885SLC6A2 45/4885SLC6A4 238/4885
US-20240239775-A1 FXR REGULATOR, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF SLC10A1, NR1H4, FXR1 IDO1 3516/4885SLC6A2 1113/4885SLC6A4 573/4885
US-20250177397-A1 INHIBITORS OF MPTP PARK7, PINK1, SNCA IDO1 225/4885SLC6A2 45/4885SLC6A4 238/4885
US-20260007672-A1 INHIBITORS OF MPTP PARK7, SNCA, CYC1 IDO1 315/4885SLC6A2 85/4885SLC6A4 189/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.