Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30442579 | 0.83 | KCNH2 (0.46) | ALDH1A1MAPK1CES2CES1HPGD | |
| SCHEMBL8236429 | 0.83 | KCNH2 (0.46) | ALDH1A1MAPK1CES2CES1HPGD | |
| SCHEMBL3920988 | 0.83 | PTPN1 (0.50) | ALDH1A1GSK3BCES2CES1HPGD | |
| SCHEMBL3094911 | 0.82 | CES2 (0.61) | ALDH1A1MAPK1HIF1AGSK3BCES2 | |
| SCHEMBL29798926 | 0.82 | CES2 (0.61) | ALDH1A1MAPK1HIF1AGSK3BCES2 | |
| SCHEMBL28238807 | 0.81 | ERCC5 (0.51) | ALDH1A1CES2CES1HPGDRAB9A | |
| SCHEMBL6818999 | 0.81 | MAOB (0.45) | ALDH1A1MAPK1HIF1ACES2CES1 | |
| SCHEMBL9526213 | 0.80 | ALDH1A1 (0.71) | ALDH1A1MAPK1HIF1AGSK3BHPGD | |
| SCHEMBL5795078 | 0.79 | KEAP1 (0.61) | ALDH1A1MAPK1HIF1AGSK3BCES2 | |
| SCHEMBL21055979 | 0.78 | ALDH1A1 (0.53) | ALDH1A1MAPK1HIF1AGSK3BERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 180 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114213630-B | Mannich modified amine epoxy resin curing agent and preparation method thereof | 上海船舶工艺研究所(中国船舶集团有限公司第十一研究所) | 2024-04-05 | — | — | CN | claimed |
| CN-117736083-A | Method for preparing 2, 4-dichloro-5-fluorobenzoic acid and 2, 6-dichloro-3-fluorobenzoic acid by taking 2, 4-dichloro-5-fluoroacetophenone crystallization mother liquor as raw material | 浙江工业大学 | 2024-03-22 | — | — | CN | claimed |
| CN-117486674-A | Comprehensive utilization method of 2, 4-dichloro-5-fluoroacetophenone crystallization mother liquor | 浙江工业大学 | 2024-02-02 | — | — | CN | claimed |
| CN-117402055-A | Resource utilization method of 2, 4-dichloro-5-fluoroacetophenone mother liquor | 浙江吉泰新材料股份有限公司 | 2024-01-16 | — | — | CN | claimed |
| CN-115448813-B | Method for preparing (S) -2, 6-dichloro-3-fluorophenylethanol | 中国科学院兰州化学物理研究所 | 2023-07-25 | — | — | CN | claimed |
| CN-111606782-B | Synthesis method of (S) -1- (2,6-dichloro-3-fluorophenyl) -ethanol | 佛山奕安赛医药科技有限公司 | 2023-03-31 | — | — | CN | claimed |
| CN-112522224-B | Alcohol dehydrogenase mutant with improved activity and stereoselectivity, recombinant vector, genetic engineering bacteria and application thereof | 华东理工大学 | 2022-12-23 | — | — | CN | claimed |
| CN-115448813-A | Method for preparing (S) -2, 6-dichloro-3-fluorophenethyl alcohol | 中国科学院兰州化学物理研究所 | 2022-12-09 | — | — | CN | claimed |
| CN-110372538-B | Synthesis method of 2, 6-dichloro-3-fluorobenzonitrile | 浙江吉泰新材料股份有限公司 | 2022-10-21 | — | — | CN | claimed |
| CN-114057556-B | Method for synthesizing fluochloroacetophenone based on acyl isomers | 山东国邦药业有限公司 | 2022-05-03 | — | — | CN | claimed |
| CN-107794282-B | Preparation method and strain of crizotinib chiral intermediate | 浙江工业大学 | 2020-12-25 | — | — | CN | claimed |
| CN-112110897-A | Preparation method of deuterated crizotinib and derivative thereof | 北京凯悦宁医药科技有限公司 | 2020-12-22 | — | — | CN | claimed |
| CN-111892488-A | Method for efficiently synthesizing 2, 6-dichloro-3-fluoro acetophenone | 惠州拓康生物科技有限公司 | 2020-11-06 | — | — | CN | claimed |
| CN-111606782-A | Synthesis method of (S) -1- (2, 6-dichloro-3-fluorophenyl) -ethanol | 中山奕安泰医药科技有限公司 | 2020-09-01 | — | — | CN | claimed |
| CN-111118072-A | Method for preparing enzatinib intermediate by enzyme method | 长兴制药股份有限公司 | 2020-05-08 | — | — | CN | claimed |
| CN-110760449-A | Geotrichum galactose ZJPH1810 and application thereof in preparation of (S) -1- (2, 6-dichloro-3-fluorophenyl) ethanol | 浙江工业大学 | 2020-02-07 | — | — | CN | claimed |
| US-9528131-B2 | Methods of using ketoreductase polypeptides for reduction of acetophenones | CODEXIS, INC. (US) | 2016-12-27 | — | — | US | claimed |
| CN-106047950-A | Biological preparation method of (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol | 尚科生物医药（上海）有限公司 | 2016-10-26 | — | — | CN | claimed |
| CN-104844412-A | Preparation method of 1,2,4-trifluorobenzene | ZHEJIANG LINJIANG CHEMICAL CO LTD | 2015-08-19 | — | — | CN | claimed |
| CN-104327053-A | Deuterated crizotinib and derivatives thereof, preparation method and application | BEIJING KYNING BIOSCIENCE CO LTD | 2015-02-04 | — | — | CN | claimed |