Benfuresate

Benfuresate

SCHEMBL4890261

CCS(=O)(=O)Oc1ccc2c(c1)C(C)(C)CO2.CCS(=O)(=O)Oc1ccc2c(c1)C(C)(C)CO2

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.41
PTGS2 P35354 1/20 0.41
NOTUM Q6P988 2/20 0.40
RARB P10826 3/20 0.39
RARG P13631 3/20 0.39
RARA P10276 2/20 0.39
ALPI P09923 2/20 0.38
ALPL P05186 1/20 0.38
CA2 P00918 2/20 0.37
RXRA P19793 1/20 0.36
MMP2 P08253 2/20 0.36
MMP9 P14780 2/20 0.36
MMP14 P50281 2/20 0.36
MMP7 P09237 1/20 0.36
HTR1A P08908 1/20 0.36
HTR2B P41595 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
ACACB O00763 1/20 0.35
CA12 O43570 1/20 0.35
ENPP3 O14638 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benfuresate SCHEMBL29396663 1.00 PTGS1 (0.41) PTGS1PTGS2NOTUMRARBRARG
Benfuresate SCHEMBL54959 1.00 PTGS1 (0.41) PTGS1PTGS2NOTUMRARBRARG
Benfuresate SCHEMBL7520848 0.96 PTGS1 (0.39) PTGS1PTGS2NOTUMRARBRARG
SCHEMBL11449645 0.91 CA12 (0.41) PTGS1PTGS2NOTUMRARBRARG
SCHEMBL11449273 0.89 PTGS1 (0.39) PTGS1PTGS2NOTUMRARBRARG
SCHEMBL11448349 0.88 ALPL (0.43) PTGS1PTGS2NOTUMRARBRARG
SCHEMBL11459578 0.87 MMP2 (0.41) PTGS1PTGS2NOTUMRARBRARG
Benfuresate SCHEMBL15634059 0.86 ACACB (0.38) PTGS1PTGS2NOTUMRARBRARG
SCHEMBL18827241 0.86 PTGS1 (0.45) PTGS1PTGS2ALPIALPLCA2
SCHEMBL11450799 0.85 CA2 (0.45) PTGS1PTGS2NOTUMRARBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 160 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3746505-B1 COMPOSITION, POLYMER COMPOSITE ARTICLE FORMED THEREWITH, AND METHOD OF PREPARING SAME DOW SILICONES CORP (US) 2024-06-26 EP disclosed
EP-3906245-B1 MULTIFUNCTIONAL ORGANOSILICON COMPOUND AND RELATED METHODS, COMPOUNDS, AND COMPOSITIONS DOW SILICONES CORP (US) 2024-05-29 EP disclosed
US-20240124709-A1 COMPOSITION, POLYMER COMPOSITE ARTICLE FORMED THEREWITH, AND METHOD OF PREPARING SAME DOW GLOBAL TECHNOLOGIES LLC 2024-04-18 US disclosed
EP-3645640-B1 SILICONE-POLYETHER COPOLYMER, METHOD OF PREPARING SAME, AND SEALANT COMPRISING SAME DOW SILICONES CORP (US) 2024-03-06 EP disclosed
US-11884821-B2 Composition, polymer composite article formed therewith, and method of preparing same DOW SILICONES CORPORATION (US) 2024-01-30 US disclosed
WO-2023215360-A1 SILICONE-POLYETHER COPOLYMER, SEALANTS COMPRISING SAME, AND RELATED METHODS DOW SILICONES CORPORATION (US) 2023-11-09 WO disclosed
US-11807775-B2 Silicone-organic copolymer, sealants comprising same, and related methods DOW SILICONES CORPORATION (US) 2023-11-07 US disclosed
US-11760841-B2 Silicone-polycarbonate copolymer, sealants comprising same, and related methods DOW SILICONES CORPORATION (US) 2023-09-19 US disclosed
CN-113272363-B Silicone-organic copolymers, sealants including silicone-organic copolymers, and related methods 美国陶氏有机硅公司 2023-02-17 CN disclosed
EP-3898779-B1 SILICONE-POLYESTER COPOLYMER, SEALANTS COMPRISING SAME, AND RELATED METHODS DOW SILICONES CORP (US) 2023-02-08 EP disclosed
WO-2013009836-A1 SAMARIUM CONTAINING COMPLEXES AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING CORPORATION (US) 2013-01-17 WO disclosed
WO-2012134784-A1 COMPOSITIONS CONTAINING PHOSPHONATE CATALYSTS AND METHODS FOR THE PREPARATION AND USE OF THE COMPOSITIONS DOW CORNING CORPORATION (US) 2012-10-04 WO disclosed
WO-2012134788-A1 COMPOSITIONS CONTAINING PHOSPHATE CATALYSTS AND METHODS FOR THE PREPARATION AND USE OF THE COMPOSITIONS DOW CORNING CORPORATION (US) 2012-10-04 WO disclosed
WO-2012134786-A1 COMPOSITIONS CONTINING SULFONIC ACID CATALYSTS AND METHODS FOR THE PREPARATION AND USE OF THE COMPOSITIONS DOW CORNING CORPORATION (US) 2012-10-04 WO disclosed
US-20080118734-A1 Coating Compositions DOW CORNING IRELAND LTD. (IE) 2008-05-22 US disclosed
EP-1744836-A2 PROCESS AND APPARATUS FOR PLASMA COATING, SUBSTRATES COATED BY THIS METHOD OR APPARATUS Dow Corning Ireland Limited (IE) 2007-01-24 EP disclosed
WO-2005110626-A2 PROCESS AND APPARATUS FOR PLASMA COATING, SUBSTRATES COATED BY THIS METOD OR APPARATUS DOW CORNING IRELAND LIMITED (IE) 2005-11-24 WO disclosed
EP-0574418-B1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1998-11-11 EP disclosed
US-5688745-A Arylsulfonylureas and their use as herbicides and growth regulators HOECHST AKTIENGESELLSCHAFT (DE) 1997-11-18 US disclosed
US-5463081-A Chemical intermediates HOECHST AKTIENGESELLSCHAFT (DE) 1995-10-31 US disclosed