Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.67 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.67 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8401704 | 0.93 | HDAC1 (0.89) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL1060598 | 0.87 | HDAC1 (0.79) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| Dinaline SCHEMBL93636 | 0.87 | HDAC1 (0.79) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| Dinaline SCHEMBL29354254 | 0.87 | HDAC1 (0.79) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL407834 | 0.87 | HDAC1 (1.00) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL30363156 | 0.87 | HDAC1 (1.00) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL7103601 | 0.87 | MEN1 (0.68) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL23500754 | 0.86 | HDAC1 (0.83) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| Dinaline SCHEMBL10373837 | 0.86 | HDAC1 (0.77) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL18361216 | 0.86 | HDAC1 (0.77) | HDAC1HDAC3HDAC2MAPK1NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240066038-A1 | WNT MODULATORS TO TREAT CENTRAL NERVOUS SYSTEM INJURIES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2024-02-29 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | UNIVERSITY OF LEEDS (GB) | 2008-09-25 | — | — | US | disclosed |
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | UNIVERSITY OF LEEDS (GB) | 2008-09-25 | — | — | US | disclosed |
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | UNIVERSITY OF LEEDS (GB) | 2008-09-25 | — | — | US | disclosed |
| EP-1758847-A1 | INHIBITORS OF HISTONE DEACETYLASE | Cancer Research Technology Limited (GB) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121073-A1 | INHIBITORS OF HISTONE DEACETYLASE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |
| WO-2005121073-A1 | INHIBITORS OF HISTONE DEACETYLASE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234254-A1 | Inhibitors of Histone Deacetylase | HDAC8, HDAC4, HDAC5 | HDAC1 4/4885HDAC3 5/4885HDAC2 7/4885 |
| US-20240066038-A1 | WNT MODULATORS TO TREAT CENTRAL NERVOUS SYSTEM INJURIES | WNT3A, WNT1, WNT3 | HDAC1 2360/4885HDAC3 2603/4885HDAC2 2861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.