Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 4/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897158 | 0.91 | MAPT (0.41) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL4789019 | 0.81 | SMN1; SMN2 (0.41) | ALDH1A1KDM4EMAPTSMN1; SMN2MEN1 | |
| SCHEMBL4788948 | 0.80 | KMT2A (0.43) | ALDH1A1MAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL2856449 | 0.75 | MAPT (0.50) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL3441956 | 0.74 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL2857034 | 0.73 | KDM4E (0.62) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL4885880 | 0.73 | CNR1 (0.39) | ALDH1A1KDM4EMAPTSMN1; SMN2HPGD | |
| SCHEMBL13513716 | 0.73 | POLB (0.59) | ALDH1A1KDM4EMAPTPOLBLMNA | |
| SCHEMBL2852931 | 0.72 | KDM4E (0.57) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL2064195 | 0.72 | MAPT (0.76) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130313-A1 | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE GABA RECEPTOR FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |