Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4887516 | 0.89 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL14511612 | 0.79 | TLR7 (0.34) | ALDH1A1HTTSMN1; SMN2LMNAADORA3 | |
| SCHEMBL3228644 | 0.78 | KMT2A (0.45) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL4895350 | 0.76 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL4889734 | 0.74 | TLR7 (0.35) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL4893882 | 0.72 | CNR2 (0.42) | ALDH1A1KDM4EHPGDHTTRAB9A | |
| SCHEMBL3228381 | 0.72 | DAPK3 (0.42) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL8940806 | 0.67 | TSHR (0.48) | ALDH1A1KDM4ESMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL10846139 | 0.66 | KMT2A (0.45) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL2843820 | 0.64 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDHTTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101341131-A | Imidazoles as gaba-b receptor modulators | ASTRAZENECA AB (SE) | 2009-01-07 | — | — | CN | claimed |
| US-20080312305-A1 | Imidazoles as Gaba- B Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | claimed |
| CN-101341131-A | Imidazoles as gaba-b receptor modulators | ASTRAZENECA AB (SE) | 2009-01-07 | — | — | CN | disclosed |
| US-20080312305-A1 | Imidazoles as Gaba- B Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312305-A1 | Imidazoles as Gaba- B Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312305-A1 | Imidazoles as Gaba- B Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312305-A1 | Imidazoles as Gaba- B Receptor Modulators | GABRB1, GABBR2, GABRB2 | ALDH1A1 1448/4885KDM4E 2544/4885HPGD 2046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.