Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Berberine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 10/20 | 0.98 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.98 |
| ▸ | BCHE | P06276 | 10/20 | 0.98 |
| ▸ | EP300 | Q09472 | 4/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | MAPT | P10636 | 2/20 | 0.98 |
| ▸ | DRD2 | P14416 | 2/20 | 0.98 |
| ▸ | TSHR | P16473 | 2/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.98 |
| ▸ | RXRA | P19793 | 2/20 | 0.98 |
| ▸ | DRD1 | P21728 | 2/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | HTT | P42858 | 2/20 | 0.98 |
| ▸ | RAD52 | P43351 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Berberine SCHEMBL29354144 | 0.99 | ACHE (1.00) | BCHEACHEEP300ALDH1A1LMNA | |
| Berberine SCHEMBL15669190 | 0.99 | ACHE (1.00) | BCHEACHEEP300ALDH1A1LMNA | |
| Berberine SCHEMBL25632 | 0.99 | ACHE (1.00) | BCHEACHEEP300ALDH1A1LMNA | |
| Berberine SCHEMBL30153843 | 0.99 | ACHE (1.00) | BCHEACHEEP300ALDH1A1LMNA | |
| Berberine SCHEMBL2538316 | 0.98 | ACHE (0.98) | BCHEACHEEP300ALDH1A1LMNA | |
| Berberine SCHEMBL3686644 | 0.98 | ACHE (0.98) | BCHEACHEEP300ALDH1A1LMNA | |
| Berberine SCHEMBL21462194 | 0.98 | ACHE (0.98) | BCHEACHEEP300ALDH1A1LMNA | |
| Berberine SCHEMBL10709599 | 0.98 | ACHE (0.98) | BCHEACHEEP300ALDH1A1LMNA | |
| Berberine SCHEMBL153906 | 0.98 | ACHE (1.00) | BCHEACHEEP300ALDH1A1LMNA | |
| Berberine SCHEMBL1376273 | 0.98 | ACHE (0.98) | BCHEACHEEP300ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117327063-B | Antibacterial medicament and application thereof | 中国医学科学院医药生物技术研究所 | 2024-03-15 | — | — | CN | disclosed |
| CN-117327063-A | Antibacterial medicament and application thereof | 中国医学科学院医药生物技术研究所 | 2024-01-02 | — | — | CN | disclosed |
| US-20080175927-A1 | extract of at least one plant selected from Coptis chinensis Franch., Phellodendron genus plant, Sanguinaria canadensis and Chelidonium majus var. asiaticum; plant powdery mildew, anthracnose of pepper, damping-off of cucumber and gray mold rot of strawberry | KOREA BIO CHEMICAL CO., LTD. (KR) | 2008-07-24 | — | — | US | disclosed |
| US-20060228428-A1 | extract of at least one plant selected from Coptis chinensis Franch., Phellodendron genus plant, Sanguinaria canadensis and Chelidonium majus var. asiaticum; plant powdery mildew, anthracnose of pepper, damping-off of cucumber and gray mold rot of strawberry | KOREA BIO CHEMICAL CO., LTD (KR) | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080175927-A1 | extract of at least one plant selected from Coptis chinensis Franch., Phellodendron genus plant, Sanguinaria canadensis and Chelidonium majus var. asiaticum; plant powdery mildew, anthracnose of pepper, damping-off of cucumber and gray mold rot of strawberry | COPS6, TIPARP, CPNE4 | ACHE 1682/4885CHRM1 1566/4885BCHE 28/4885 |
| US-20060228428-A1 | extract of at least one plant selected from Coptis chinensis Franch., Phellodendron genus plant, Sanguinaria canadensis and Chelidonium majus var. asiaticum; plant powdery mildew, anthracnose of pepper, damping-off of cucumber and gray mold rot of strawberry | COPS6, TIPARP, CPNE4 | ACHE 1682/4885CHRM1 1566/4885BCHE 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.