Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.37 |
| ▸ | MAPT | P10636 | 10/20 | 0.36 |
| ▸ | MEN1 | O00255 | 8/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532187 | 0.82 | ALDH1A1 (0.49) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL4896130 | 0.81 | ALDH1A1 (0.53) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL4760642 | 0.78 | ALDH1A1 (0.40) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL4762728 | 0.70 | MAPT (0.39) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL4720475 | 0.70 | BCAT2 (0.42) | ALDH1A1MAPTKMT2AKDM4EHPGD | |
| SCHEMBL4891790 | 0.69 | ALDH1A1 (0.41) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL6706191 | 0.68 | ALDH1A1 (0.45) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL4760669 | 0.66 | HTT (0.44) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL4762615 | 0.66 | ALDH1A1 (0.45) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL4564935 | 0.64 | ALDH1A1 (0.70) | ALDH1A1MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458722-B1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2008-10-15 | — | — | EP | disclosed |
| EP-1458722-A1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GmbH (DE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055882-A1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2003-07-10 | — | — | WO | disclosed |