SCHEMBL4895048

SCHEMBL4895048

C=C1CC(=O)N(CCCl)C1=O

nearest known ligand 0.32

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.32
KMT2A Q03164 3/20 0.32
MEN1 O00255 2/20 0.32
USP2 O75604 2/20 0.32
BLM P54132 2/20 0.32
KDM4E B2RXH2 1/20 0.32
POLB P06746 1/20 0.32
RECQL P46063 1/20 0.32
GAA P10253 2/20 0.32
HSD17B10 Q99714 2/20 0.32
HTT P42858 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
APAF1 O14727 1/20 0.30
ALDH1A1 P00352 1/20 0.30
CASP1 P29466 1/20 0.30
RAB9A P51151 1/20 0.30
CASP7 P55210 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6835923 0.87 MAPT (0.35) MAPTKMT2AMEN1USP2BLM
SCHEMBL13864166 0.81 MAPT (0.43) MAPTKMT2AMEN1USP2BLM
SCHEMBL4903716 0.79 CYP19A1 (0.33) MAPTKMT2AMEN1USP2BLM
SCHEMBL5175560 0.79 KDM4E (0.35) MAPTKMT2AMEN1USP2BLM
SCHEMBL409034 0.76 KDM4E (0.44) MAPTKMT2AMEN1USP2BLM
SCHEMBL4449441 0.76 MGLL (0.45) MAPTKMT2AMEN1USP2BLM
SCHEMBL11136205 0.75 MGLL (0.44) MAPTKMT2AMEN1USP2BLM
SCHEMBL411262 0.74 F2 (0.40) MAPTBLMALDH1A1CASP1
SCHEMBL410345 0.73 MGLL (0.47) MAPTKMT2AMEN1USP2BLM
SCHEMBL5970022 0.73 MGLL (0.47) MAPTKMT2AMEN1USP2BLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080003288-A1 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2008-01-03 US disclosed
US-7204997-B2 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2007-04-17 US disclosed
EP-1478403-A1 RESPONSIVE MICROGEL AND METHODS RELATED THERETO SUPRATEK PHARMA, INC. (CA) 2004-11-24 EP disclosed
US-20030152623-A1 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2003-08-14 US disclosed
WO-2003063909-A1 RESPONSIVE MICROGEL AND METHODS RELATED THERETO SUPRATEK PHARMA INC. (US) 2003-08-07 WO disclosed
EP-0910351-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. Searle & Co. (US) 1999-04-28 EP disclosed
WO-1997049387-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. SEARLE AND CO. (US) 1997-12-31 WO disclosed
US-5626910-A CONTACTING RESIN WITH FLUORINE GAS FOR SURFACE MODIFIED MOLDED PRODUCT MITSUBISHI CHEMICAL CORPORATION (JP) 1997-05-06 US disclosed
EP-0585662-A1 Surface-modified molded product of synthetic resin and process for producing it Mitsubishi Chemical Corporation (JP) 1994-03-09 EP disclosed