Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 1/20 | 0.66 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.66 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.66 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | SDHB | P21912 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680584 | 0.86 | GABRG2 (0.53) | GABRG2GABRB3GABRA5GABRA3TSHR | |
| SCHEMBL28490522 | 0.85 | TSHR (0.57) | GABRG2GABRB3GABRA5GABRA3TSHR | |
| SCHEMBL1221576 | 0.84 | TSHR (0.67) | GABRG2GABRB3GABRA5GABRA3TSHR | |
| SCHEMBL29410906 | 0.84 | TSHR (0.67) | GABRG2GABRB3GABRA5GABRA3TSHR | |
| SCHEMBL6714723 | 0.84 | CA12 (0.52) | GABRG2GABRB3GABRA5GABRA3CDK8 | |
| SCHEMBL30107993 | 0.84 | CDK8 (0.54) | GABRG2GABRB3GABRA5GABRA3TSHR | |
| SCHEMBL6718372 | 0.84 | CNR1 (0.56) | GABRG2GABRB3GABRA5GABRA3CDK8 | |
| SCHEMBL5562975 | 0.84 | GRM5 (0.64) | GABRG2GABRB3GABRA5GABRA3TSHR | |
| SCHEMBL3359577 | 0.83 | CA12 (0.65) | GABRG2GABRB3GABRA5GABRA3TSHR | |
| Hydrochloric Acid SCHEMBL29506745 | 0.83 | CA12 (0.65) | GABRG2GABRB3GABRA5GABRA3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229818-A1 | Compounds for Nonsense Suppression, and Methods for Their Use | PTC THERAPEUTICS, INC. (US) | 2016-08-11 | — | — | US | disclosed |
| US-9315467-B2 | Compounds for nonsense suppression, and methods for their use | PTC THERAPEUTICS, INC. (US) | 2016-04-19 | — | — | US | disclosed |
| US-20080119473-A1 | Compounds for Nonsense Suppression, and Methods for Their Use | PTC THERAPEUTICS, INC. | 2008-05-22 | — | — | US | disclosed |
| EP-1799212-A2 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC Therapeutics, Inc. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006044505-A2 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119473-A1 | Compounds for Nonsense Suppression, and Methods for Their Use | NSUN2, UPF1, NSUN3 | GABRG2 2136/4885GABRB3 1676/4885GABRA5 2656/4885 |
| US-20160229818-A1 | Compounds for Nonsense Suppression, and Methods for Their Use | NSUN2, UPF1, NSUN3 | GABRG2 2136/4885GABRB3 1676/4885GABRA5 2656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.