Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 1/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | SDHB | P21912 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 2/20 | 0.49 |
| ▸ | PLAU | P00749 | 2/20 | 0.49 |
| ▸ | ERN1 | O75460 | 2/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680471 | 0.86 | TDP1 (0.50) | CA12CA1CA2CA9GRM5 | |
| SCHEMBL4895475 | 0.86 | GABRG2 (0.66) | GABRG2GABRB3GABRA5GABRA3CDK8 | |
| SCHEMBL6714723 | 0.83 | CA12 (0.52) | GABRG2GABRB3GABRA5GABRA3CDK8 | |
| SCHEMBL6718372 | 0.83 | CNR1 (0.56) | GABRG2GABRB3GABRA5GABRA3CDK8 | |
| SCHEMBL30107993 | 0.83 | CDK8 (0.54) | GABRG2GABRB3GABRA5GABRA3CDK8 | |
| SCHEMBL5557467 | 0.83 | CDK8 (0.57) | GABRG2GABRB3GABRA5GABRA3CDK8 | |
| SCHEMBL13680552 | 0.82 | CYP2A6 (0.53) | CDK8ABL1GRM5CYP2A6CCR1 | |
| SCHEMBL14189314 | 0.82 | KMO (0.55) | GRM5CYP2A6NPC1RAB9ACCR1 | |
| SCHEMBL8817643 | 0.82 | PDE5A (0.53) | GABRG2GABRB3GABRA5GABRA3GRM5 | |
| SCHEMBL16553302 | 0.81 | GABRG2 (0.53) | GABRG2GABRB3GABRA5GABRA3CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |