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SCHEMBL4895596

SCHEMBL4895596

COC(=O)c1cc(S(=O)(=O)N(CCc2ccc(OCc3cccc(F)c3F)cc2)Cc2cccc(F)c2F)ccc1C

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.42
▸ TAS2R14 Q9NYV8 2/20 0.40
▸ TP53 P04637 2/20 0.39
▸ CA12 O43570 2/20 0.39
▸ CA1 P00915 2/20 0.39
▸ CA2 P00918 2/20 0.39
▸ CA4 P22748 2/20 0.39
▸ CA9 Q16790 2/20 0.39
▸ BMP1 P13497 2/20 0.38
▸ KEAP1 Q14145 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ MEN1 O00255 1/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4906456 0.92 TAS2R14 (0.43) TAS2R14TP53CA12CA1CA2
SCHEMBL4906305 0.84 TP53 (0.47) LMNATP53ALDH1A1GAAMEN1
SCHEMBL4904285 0.83 TP53 (0.45) LMNATAS2R14TP53CA12CA1
SCHEMBL4900038 0.83 TAS2R14 (0.46) LMNATAS2R14TP53CA12CA1
SCHEMBL4904145 0.82 MMP2 (0.45) LMNATAS2R14TP53CA12CA1
SCHEMBL4895626 0.82 TAS2R14 (0.56) LMNATAS2R14TP53CA12CA1
SCHEMBL4906315 0.81 LMNA (0.46) LMNAKEAP1ALDH1A1MEN1NPC1
SCHEMBL4908413 0.81 CNR2 (0.48) LMNATAS2R14TP53CA12CA1
SCHEMBL4905637 0.80 TAS2R14 (0.44) LMNATAS2R14TP53CA12CA1
SCHEMBL4902732 0.79 KMT2A (0.48) TAS2R14TP53CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD LMNA 317/4885TAS2R14 4063/4885TP53 3260/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD LMNA 319/4885TAS2R14 4032/4885TP53 3421/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD LMNA 319/4885TAS2R14 4032/4885TP53 3421/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.