Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | BUB1 | O43683 | 7/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895681 | 1.00 | ALDH1A1 (0.42) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL4896668 | 0.85 | ALDH1A1 (0.44) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL4243862 | 0.82 | BUB1 (0.53) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL4243859 | 0.82 | BUB1 (0.53) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL10953757 | 0.67 | METAP1 (0.46) | SMN1; SMN2BUB1TSHR | |
| SCHEMBL4242404 | 0.67 | ATM (0.48) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL19417742 | 0.66 | HSD11B1 (0.42) | NPC1RAB9A | |
| SCHEMBL9704433 | 0.63 | MAPT (0.53) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL9704429 | 0.63 | MAPT (0.53) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL4889582 | 0.63 | BUB1 (0.35) | NSD2BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113962-A1 | Condensed Tricyclic Benzimidazoles For the Treatment of Gastrointestinal Disorders | AITANA PHARMA AG (DE) | 2008-05-15 | — | — | US | disclosed |
| US-20070244154-A1 | Substituted Tricyclic Benzimidazoles | ALTANA PHARMA AG (DE) | 2007-10-18 | — | — | US | disclosed |
| EP-1758900-B1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES | NYCOMED GMBH (DE) | 2007-10-03 | — | — | EP | disclosed |
| EP-1799681-A1 | CONDENSED TRICYCLIC BENZIMIDAZOLES FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | Altana Pharma AG (DE) | 2007-06-27 | — | — | EP | disclosed |
| EP-1758900-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES | Altana Pharma AG (DE) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006037759-A1 | CONDENSED TRICYCLIC BENZIMIDAZOLES FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ALTANA PHARMA AG (DE) | 2006-04-13 | — | — | WO | disclosed |
| WO-2005121139-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES | ALTANA PHARMA AG (DE) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113962-A1 | Condensed Tricyclic Benzimidazoles For the Treatment of Gastrointestinal Disorders | PGC, SI, VIP | ALDH1A1 1947/4885MAPT 3207/4885MEN1 2504/4885 |
| US-20070244154-A1 | Substituted Tricyclic Benzimidazoles | VIP, GIPR, SLC10A2 | ALDH1A1 510/4885MAPT 4763/4885MEN1 2333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.