Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896400 | 1.00 | POLB (0.31) | POLBHDAC6F2HDAC3HDAC4 | |
| SCHEMBL4896372 | 0.81 | HDAC6 (0.36) | POLBHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL4896345 | 0.79 | ALDH1A1 (0.30) | ALDH1A1GAAHPGD | |
| SCHEMBL4888010 | 0.74 | F2 (0.36) | HDAC6F2HDAC3HDAC4HDAC1 | |
| SCHEMBL3342250 | 0.59 | POLB (0.44) | POLBGAA | |
| SCHEMBL4094120 | 0.58 | HDAC1 (0.45) | HDAC6HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL366720 | 0.58 | EGLN1 (0.47) | POLBALDH1A1HPGD | |
| SCHEMBL11139095 | 0.58 | EGLN1 (0.47) | POLBALDH1A1HPGD | |
| SCHEMBL16866627 | 0.57 | MAPK1 (0.64) | ALDH1A1 | |
| SCHEMBL17102267 | 0.57 | ADRA2C (0.37) | F2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080193377-A1 | Radiolabeled Nanohybrids Targeting Solid Tumor Neovasculature and Method of Using Same | UNIVERSITY OF MARYLAND, BALTIMORE | 2008-08-14 | — | — | US | disclosed |
| EP-1768706-A2 | RADIOLABELED NANOHYBRIDS TARGETING SOLID TUMOR NEOVASCULATURE AND METHOD OF USING SAME | University of Maryland, Baltimore (US) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006012355-A2 | RADIOLABELED NANOHYBRIDS TARGETING SOLID TUMOR NEOVASCULATURE AND METHOD OF USING SAME | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2006-02-02 | — | — | WO | disclosed |