Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10870987 | 0.82 | TSHR (0.49) | HDAC1HDAC6HDAC2HDAC3HDAC4 | |
| SCHEMBL10652606 | 0.78 | CHRM2 (0.64) | LMNAHRH1CHRM2ADRA2AADRA2B | |
| SCHEMBL10651082 | 0.77 | KCNH2 (0.43) | LMNAHRH1CHRM2ADRA2AADRA2B | |
| SCHEMBL10654586 | 0.77 | HRH1 (0.43) | LMNAHRH1CHRM2ADRA2AADRA2B | |
| SCHEMBL21837117 | 0.76 | LMNA (0.41) | HDAC1HDAC6HDAC2HDAC3HDAC4 | |
| SCHEMBL2474794 | 0.76 | CXCR4 (0.50) | HDAC1HDAC6HDAC2HDAC3HDAC4 | |
| SCHEMBL4094117 | 0.76 | CXCR4 (0.50) | HDAC1HDAC6HDAC2HDAC3HDAC4 | |
| SCHEMBL915614 | 0.76 | TSHR (0.46) | HDAC1HDAC6HDAC2HDAC3HDAC4 | |
| SCHEMBL10652605 | 0.74 | GBA1 (0.66) | LMNAHRH1CHRM2ADRA2AADRA2B | |
| SCHEMBL10654502 | 0.73 | CHRM2 (0.45) | LMNAHRH1CHRM2ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440841-B2 | 5-pyrrolidinylsulfonyl isatin derivatives | Universitätsklinikum Münster (DE) | 2013-05-14 | — | — | US | disclosed |
| US-20090041664-A1 | 5-Pyrrolidinylsulfonyl Isatin Derivatives | UNIVERSITATSKLINIKUM MUNSTER (DE) | 2009-02-12 | — | — | US | disclosed |
| EP-1682113-B1 | INHIBITOR IMAGING AGENTS | GE HEALTHCARE LTD (GB) | 2008-01-23 | — | — | EP | disclosed |
| EP-1841759-A2 | 5-PYRROLIDINYLSULFONYL ISATIN DERIVATIVES | Universitätsklinikum Münster (DE) | 2007-10-10 | — | — | EP | disclosed |
| US-20070184537-A1 | Method for the linkage of bifunctional chelating agents and (radioactive) transition metal complexes to proteins and peptides | PAUL SCHERRER INSTITUT (CH) | 2007-08-09 | — | — | US | disclosed |
| US-20070104644-A1 | Inhibitor imaging agents | CUTHBERTSON ALAN | 2007-05-10 | — | — | US | disclosed |
| CN-1901894-A | Inhibitor imaging agents | GE HEALTHCARE LTD (GB) | 2007-01-24 | — | — | CN | disclosed |
| EP-1682113-A1 | INHIBITOR IMAGING AGENTS | GE Healthcare Limited (GB) | 2006-07-26 | — | — | EP | disclosed |
| WO-2006074799-A2 | 5-PYRROLIDINYLSULFONYL ISATIN DERIVATIVES | Universitätsklinikum Münster (DE) | 2006-07-20 | — | — | WO | disclosed |
| WO-2005049005-A1 | INHIBITOR IMAGING AGENTS | GE HEALTHCARE LIMITED (GB) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090041664-A1 | 5-Pyrrolidinylsulfonyl Isatin Derivatives | CASP5, CTSZ, CTSS | HDAC1 2391/4885HDAC6 1214/4885HDAC2 2826/4885 |
| US-20070184537-A1 | Method for the linkage of bifunctional chelating agents and (radioactive) transition metal complexes to proteins and peptides | EPRS1, SLC7A11, QPCTL | HDAC1 1627/4885HDAC6 1675/4885HDAC2 2824/4885 |
| US-20070104644-A1 | Inhibitor imaging agents | MMP3, MMP1, MMP10 | HDAC1 63/4885HDAC6 101/4885HDAC2 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.