Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GPX4 | P36969 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28725225 | 0.77 | CES2 (0.38) | ALDH1A1GSK3B | |
| SCHEMBL3658261 | 0.76 | HSD17B10 (0.50) | CYP3A4SMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL1097782 | 0.75 | CYP3A4 (0.50) | CYP3A4LMNASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL17652108 | 0.75 | SMN1; SMN2 (0.48) | CYP3A4SMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL29531411 | 0.75 | SMN1; SMN2 (0.48) | CYP3A4SMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL17462499 | 0.75 | SMN1; SMN2 (0.45) | MTNR1AMTNR1BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1097516 | 0.74 | MTNR1A (0.52) | CYP3A4MTNR1AMTNR1BLMNATP53 | |
| SCHEMBL1096970 | 0.74 | CA1 (0.54) | CYP3A4MTNR1AMTNR1BLMNASMN1; SMN2 | |
| SCHEMBL31552285 | 0.73 | HSD17B10 (0.41) | CYP3A4MTNR1AMTNR1BNPSR1MEN1 | |
| SCHEMBL10620598 | 0.73 | MEP1B (0.40) | LMNASMN1; SMN2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663255-B1 | WITHANAMIDE AND WITHANOLIDE COMPOSITIONS AND METHOD OF USE THEREOF | UNIV MICHIGAN STATE (US) | 2014-11-12 | — | — | EP | disclosed |
| US-20080108694-A1 | Novel Macrocycles and Uses Thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2008-05-08 | — | — | US | disclosed |
| US-7282593-B2 | Withanamide and withanolide compositions and method of use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2007-10-16 | — | — | US | disclosed |
| EP-1663255-A2 | WITHANAMIDE AND WITHANOLIDE COMPOSITIONS AND METHOD OF USE THEREOF | Michigan State University (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005061481-A1 | NOVEL MA CROCYCLES AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005034846-A2 | WITHANAMIDE AND WITHANOLIDE COMPOSITIONS AND METHOD OF USE THEREOF | MICHIGAN STATE UNIVERSITY (US) | 2005-04-21 | — | — | WO | disclosed |
| US-20050059727-A1 | Withanamide and withanolide compositions and method of use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108694-A1 | Novel Macrocycles and Uses Thereof | BDKRB1, RPS4Y1, GRK4 | CYP3A4 378/4885MTNR1A 1915/4885MTNR1B 2006/4885 |
| US-20050059727-A1 | Withanamide and withanolide compositions and method of use thereof | ACHE, CYP51A1, HASPIN | CYP3A4 469/4885MTNR1A 634/4885MTNR1B 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.