Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5605399 | 0.87 | MAPK1 (0.57) | MAPK1KDM4EGAAMAPTLMNA | |
| SCHEMBL3100738 | 0.82 | GAA (0.56) | MAPK1KDM4EGAAMAPTLMNA | |
| SCHEMBL3103923 | 0.81 | GAA (0.53) | MAPK1KDM4EGAAMAPTLMNA | |
| SCHEMBL3101191 | 0.81 | GAA (0.57) | MAPK1KDM4EGAAMAPTLMNA | |
| SCHEMBL3097222 | 0.78 | KDM4E (0.56) | MAPK1KDM4EGAAMAPTLMNA | |
| SCHEMBL9251960 | 0.76 | GAA (0.50) | MAPK1KDM4EGAAMAPTLMNA | |
| SCHEMBL5613204 | 0.75 | MAPT (0.57) | MAPK1KDM4EGAAMAPTLMNA | |
| SCHEMBL5613203 | 0.75 | MAPT (0.57) | MAPK1KDM4EGAAMAPTLMNA | |
| SCHEMBL5604541 | 0.75 | GAA (0.49) | MAPK1KDM4EGAAMAPTLMNA | |
| SCHEMBL6139458 | 0.74 | KMT2A (0.72) | MAPK1KDM4EGAAMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280920-A1 | Plasminogen Activator Inhibitor-1 Inhibitors | AMERICAN DIAGNOSTICA INC. | 2008-11-13 | — | — | US | disclosed |
| EP-1960395-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS | American Diagnostica Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007065261-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS | AMERICAN DIAGNOSTICA INC. (US) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280920-A1 | Plasminogen Activator Inhibitor-1 Inhibitors | SERPINE1, SERPINC1, SERPINB1 | MAPK1 1678/4885KDM4E 4282/4885GAA 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.