Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 8/20 | 0.72 |
| ▸ | THRA | P10827 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.57 |
| ▸ | ABAT | P80404 | 1/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylbenzene SCHEMBL27614422 | 0.86 | AKT1 (0.70) | THRBTHRAMEN1KMT2AALDH1A1 | |
| SCHEMBL4904680 | 0.84 | THRB (1.00) | THRBTHRAMEN1KMT2AALDH1A1 | |
| SCHEMBL4256312 | 0.82 | ALDH5A1 (0.80) | THRBTHRAMEN1KMT2AALDH1A1 | |
| SCHEMBL10954360 | 0.81 | THRB (1.00) | THRBTHRAMEN1KMT2ATDP1 | |
| SCHEMBL13562474 | 0.81 | THRB (0.63) | THRBTHRAMEN1KMT2AALDH1A1 | |
| SCHEMBL1483694 | 0.81 | ALDH1A1 (0.59) | THRBTHRAMEN1KMT2AALDH1A1 | |
| SCHEMBL21176949 | 0.80 | ALDH1A1 (0.53) | THRBTHRAMEN1KMT2AALDH1A1 | |
| SCHEMBL14192435 | 0.80 | THRB (0.90) | THRBTHRAMEN1KMT2AALDH1A1 | |
| SCHEMBL12333995 | 0.79 | THRB (0.53) | THRBTHRAMEN1KMT2AALDH1A1 | |
| SCHEMBL23658997 | 0.79 | ALDH1A1 (0.57) | THRBTHRAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116693-B | Method for preparing sofosbuvir by combining 3, 3-diaryl acrolein and Grignard reagent | 江苏科本药业有限公司 | 2021-04-27 | — | — | CN | claimed |
| CN-111116693-A | Method for preparing sofosbuvir by combining 3, 3-diaryl acrolein and Grignard reagent | 江苏科本药业有限公司 | 2020-05-08 | — | — | CN | claimed |
| US-3997708-A | ADDITION | PHILLIPS PETROLEUM COMPANY (US) | 1976-12-14 | — | — | US | claimed |
| CN-111116693-B | Method for preparing sofosbuvir by combining 3, 3-diaryl acrolein and Grignard reagent | 江苏科本药业有限公司 | 2021-04-27 | — | — | CN | disclosed |
| CN-111116693-A | Method for preparing sofosbuvir by combining 3, 3-diaryl acrolein and Grignard reagent | 江苏科本药业有限公司 | 2020-05-08 | — | — | CN | disclosed |
| US-20170305893-A1 | HETEROCYCLIC COMPOUNDS AS DCTPP1 MODULATORS | THOMAS HELLEDAYS STIFTELSE FOR MEDICINSK FORSKNING (SE) | 2017-10-26 | — | — | US | disclosed |
| US-8937091-B2 | Inhibitor of protein crosslinking and use of the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2015-01-20 | — | — | US | disclosed |
| US-8937091-B2 | Inhibitor of protein crosslinking and use of the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2015-01-20 | — | — | US | disclosed |
| WO-2014209241-A1 | METHOD FOR CROSS-LINKING OF POLYMER FILMS | ÚSTAV POLYMÉROV SAV (SK) | 2014-12-31 | — | — | WO | disclosed |
| US-20120277423-A1 | PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY | 2012-11-01 | — | — | US | disclosed |
| US-20120277423-A1 | PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY | 2012-11-01 | — | — | US | disclosed |
| EP-1478403-A1 | RESPONSIVE MICROGEL AND METHODS RELATED THERETO | SUPRATEK PHARMA, INC. (CA) | 2004-11-24 | — | — | EP | disclosed |
| US-20030152623-A1 | Responsive microgel and methods related thereto | SUPRATEK PHARMA INC. (CA) | 2003-08-14 | — | — | US | disclosed |
| WO-2003063909-A1 | RESPONSIVE MICROGEL AND METHODS RELATED THERETO | SUPRATEK PHARMA INC. (US) | 2003-08-07 | — | — | WO | disclosed |
| EP-0910351-A1 | PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS | G.D. Searle & Co. (US) | 1999-04-28 | — | — | EP | disclosed |
| EP-0907666-A1 | PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS | G.D. Searle & Co. (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997049736-A2 | PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS | G.D. SEARLE AND CO. (US) | 1997-12-31 | — | — | WO | disclosed |
| WO-1997049387-A1 | PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS | G.D. SEARLE AND CO. (US) | 1997-12-31 | — | — | WO | disclosed |
| US-4061638-A | Organocalciumpyridine-type polymerization initiators | PHILLIPS PETROLEUM COMPANY (US) | 1977-12-06 | — | — | US | disclosed |
| US-3997708-A | ADDITION | PHILLIPS PETROLEUM COMPANY (US) | 1976-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305893-A1 | HETEROCYCLIC COMPOUNDS AS DCTPP1 MODULATORS | DCTPP1, ENPP1, PPA1 | THRB 4105/4885THRA 4463/4885MEN1 2500/4885 |
| US-20120277423-A1 | PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME | ARGLU1, F12, CDKL1 | THRB 3278/4885THRA 3028/4885MEN1 1889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.