Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | DKK1 | O94907 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.40 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | PRKX | P51817 | 2/20 | 0.40 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903644 | 0.83 | DKK1 (0.40) | MEN1KMT2AGSK3BDKK1MAPK1 | |
| SCHEMBL4895715 | 0.81 | NEK1 (0.47) | GSK3BDKK1ROCK2ROCK1CLK4 | |
| SCHEMBL4906716 | 0.81 | NEK1 (0.47) | GSK3BDKK1ROCK2ROCK1CLK4 | |
| SCHEMBL4906253 | 0.77 | DKK1 (0.36) | MEN1KMT2AGSK3BDKK1MAPK1 | |
| SCHEMBL4904630 | 0.77 | DKK1 (0.36) | MEN1KMT2AGSK3BDKK1MAPK1 | |
| SCHEMBL4904704 | 0.77 | MAPK1 (0.41) | GSK3BDKK1MAPK1CDK1CDK5 | |
| SCHEMBL4902914 | 0.77 | TRHDE (0.38) | GSK3BDKK1MAPK1CDK2CLK1 | |
| SCHEMBL3651697 | 0.77 | DYRK1A (0.54) | MEN1KMT2AGSK3BDKK1CLK4 | |
| SCHEMBL4902912 | 0.77 | DKK1 (0.39) | GSK3BDKK1MAPK1SIRT2PIK3CA | |
| SCHEMBL3651561 | 0.76 | MAPK8 (0.55) | MEN1KMT2AGSK3BDKK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2008-11-20 | — | — | US | claimed |
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT3A, CTNNB1, WNT1 | MEN1 3636/4885KMT2A 3865/4885KDM4E 4436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.