SCHEMBL4900295

SCHEMBL4900295

CC(C)(C)[Si](C)(C)c1ccc2c(c1)Cc1cc([Si](C)(C)C(C)(C)C)ccc1-2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.39
NR1H3 Q13133 1/20 0.39
RAB9A P51151 4/20 0.37
MAPT P10636 3/20 0.37
NPC1 O15118 2/20 0.37
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HSD17B1 P14061 1/20 0.33
KMT2A Q03164 2/20 0.32
KCNH2 Q12809 1/20 0.31
MEN1 O00255 1/20 0.31
CASP6 P55212 1/20 0.31
GFER P55789 1/20 0.31
CYP1A2 P05177 1/20 0.30
ADRA2A P08913 1/20 0.30
MAOA P21397 1/20 0.30
SLC6A2 P23975 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4899827 0.88 NR1H2 (0.39) NR1H2NR1H3MAPT
SCHEMBL4900031 0.79 RAB9A (0.42) RAB9AMAPTNPC1KDM4EALDH1A1
SCHEMBL25470451 0.73 MAPT (0.38) RAB9AMAPTNPC1KDM4EALDH1A1
SCHEMBL30366738 0.72 NPC1 (0.40) NR1H2NR1H3RAB9AMAPTNPC1
SCHEMBL30211024 0.71 RAB9A (0.41) NR1H2NR1H3RAB9AMAPTNPC1
SCHEMBL3312462 0.68 NR1H2 (0.42) NR1H2NR1H3ALDH1A1LMNA
SCHEMBL10357234 0.68 METAP1 (0.46) RAB9AMAPTNPC1KDM4EALDH1A1
SCHEMBL28153297 0.67 NR1H2 (0.46) NR1H2NR1H3RAB9AMAPTKDM4E
SCHEMBL19256277 0.66 NR1H2 (0.54) NR1H2NR1H3
SCHEMBL40372 0.66 ALDH1A1 (0.45) RAB9AMAPTNPC1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8084559-B2 Ethylene-vinylcyclohexane copolymers SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-27 US disclosed
US-20080161514-A1 Transition Metal Complex, Process For Producing Said Transition Metal Complex, Substituent-Carrying Fluorene Compound, Process For Producing Said Fluorene Compound, Catalyst Component For Olefin Polymerization, Catalyst For Olefin Polymerization, and Process For Producing Olefin Polymer SUMITOMO CHEMICAL COMPANY, LIMTIED (JP) 2008-07-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161514-A1 Transition Metal Complex, Process For Producing Said Transition Metal Complex, Substituent-Carrying Fluorene Compound, Process For Producing Said Fluorene Compound, Catalyst Component For Olefin Polymerization, Catalyst For Olefin Polymerization, and Process For Producing Olefin Polymer AOC2, ACSL1, ACSL3 NR1H2 105/4885NR1H3 94/4885RAB9A 1868/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.