Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CERT1 | Q9Y5P4 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NAAA | Q02083 | 2/20 | 0.36 |
| ▸ | UGCG | Q16739 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15880312 | 0.77 | ASAH1 (0.47) | ASAH1ALDH1A1ACER2CES2CES1 | |
| SCHEMBL9500857 | 0.76 | ASAH1 (0.43) | ASAH1ALDH1A1ACER2CES2CES1 | |
| SCHEMBL15880443 | 0.76 | ASAH1 (0.49) | ASAH1ALDH1A1ACER2CES2CES1 | |
| SCHEMBL27853047 | 0.71 | DNM1 (0.44) | ASAH1ALDH1A1ACER2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL235674 | 0.71 | NAAA (0.66) | ASAH1ALDH1A1HTTNAAALMNA | |
| SCHEMBL855605 | 0.70 | NPSR1 (0.42) | ASAH1ALDH1A1ACER2CES2CES1 | |
| SCHEMBL28013121 | 0.69 | LMNA (0.42) | ASAH1ALDH1A1ACER2CES2CES1 | |
| SCHEMBL31494749 | 0.68 | CSNK1E (0.45) | MEN1KMT2AEPHX2 | |
| Hydrochloric Acid SCHEMBL233516 | 0.67 | MEN1 (0.45) | ASAH1ALDH1A1MEN1KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL11703706 | 0.67 | MEN1 (0.45) | ASAH1ALDH1A1MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1576083-B1 | LAUNDRY TREATMENT COMPOSITIONS | UNILEVER PLC (GB) | 2008-11-05 | — | — | EP | disclosed |