SCHEMBL490210

SCHEMBL490210

COc1ccc(/C=C/C(=O)O)c(C(C)C)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.53
ATM Q13315 1/20 0.53
MAPT P10636 3/20 0.51
ALDH1A1 P00352 2/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
KDM4E B2RXH2 1/20 0.50
GAA P10253 1/20 0.50
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
JUN P05412 1/20 0.48
NFKB1 P19838 1/20 0.48
TNFRSF1A P19438 1/20 0.47
ESR1 P03372 1/20 0.46
PTGS2 P35354 2/20 0.45
HDAC8 Q9BY41 1/20 0.45
LY96 Q9Y6Y9 1/20 0.45
ABCG2 Q9UNQ0 1/20 0.44
PTGS1 P23219 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL490211 1.00 THRB (0.53) THRBATMMAPTALDH1A1MEN1
SCHEMBL29046248 0.93 KDM4E (0.47) THRBATMMAPTALDH1A1MEN1
SCHEMBL16266993 0.87 THRB (0.51) THRBATMMAPTALDH1A1MEN1
SCHEMBL16266990 0.87 THRB (0.51) THRBATMMAPTALDH1A1MEN1
SCHEMBL4884740 0.84 MAPT (0.48) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL5799208 0.84 THRB (0.46) THRBATMMAPTALDH1A1MEN1
SCHEMBL490255 0.84 THRB (0.49) THRBATMMAPTALDH1A1MEN1
SCHEMBL5085445 0.84 THRB (0.49) THRBATMMAPTALDH1A1MEN1
SCHEMBL5799211 0.84 THRB (0.46) THRBATMMAPTALDH1A1MEN1
Isopropyl 3-(4-Isopropylphenyl)Acrylate SCHEMBL28526350 0.83 KDM4E (0.52) THRBATMMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 409 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10620481-B2 Optical alignment film composition, optical alignment film, optical laminate, and image display device FUJIFILM CORPORATION (JP) 2020-04-14 US claimed
EP-2662068-B1 OIL-IN-WATER EMULSION COMPOSITION KAO CORP (JP) 2017-07-05 EP claimed
EP-2913052-A1 Phototherapy compositions and methods OMJ Ireland Limited (PR) 2015-09-02 EP claimed
US-8772224-B2 Perfuming solution stabilized with respect to ultraviolet radiation LVMH RECHERCHE (FR) 2014-07-08 US claimed
US-20130045913-A1 PERFUMING SOLUTION STABILIZED WITH RESPECT TO ULTRAVIOLET RADIATION LVMH RECHERCHE (FR) 2013-02-21 US claimed
EP-1595936-B1 COMPOSITION FOR EXTERNAL USE VITAMIN C60 BIORES CORP (JP) 2011-10-19 EP claimed
US-20100047185-A1 ACTVIE SUBSTANCE COMBINATION ISDIN S.A. (ES) 2010-02-25 US claimed
WO-2008083975-A1 LIGHT-STABILIZED COMPOSITION ISDIN S.A. (ES) 2008-07-17 WO claimed
WO-2008083974-A1 ACTIVE SUBSTANCE COMBINATION ISDIN S.A. (ES) 2008-07-17 WO claimed
WO-2008067928-A1 UV ABSORBING COMPOSITIONS CONTAINING A PYRROLYLTRIAZINE ISDIN S.A. (ES) 2008-06-12 WO claimed
EP-0308543-B1 COMPOSITIONS FOR EXTERNAL APPLICATION Sansho Seiyaku Co., Ltd. (JP) 1993-09-22 EP claimed
WO-2026105865-A1 STRATUM CORNEUM LAYER RETENTION IMPROVER, SHININESS INHIBITOR, AND SKIN EXTERNAL COMPOSITION CONTAINING SAME 日清オイリオグループ株式会社 2026-05-21 WO disclosed
WO-2026106274-A1 HAIR COSMETIC COMPOSITION HAVING EXCELLENT PHOTOPROTECTIVE EFFICACY 한국콜마주식회사 2026-05-21 WO disclosed
US-12589062-B2 Powdery solid cosmetic preparation SHISEIDO COMPANY, LTD. (JP) 2026-03-31 US disclosed
US-20260078211-A1 A SOLID PARTICLE OF ORGANOSILICON-FUNCTIONAL CO-POLYMER, MANUFACTURING PROCESS THEREOF, AND COSMETICS COMPRISING SAID SOLID PARTICLE DOW TORAY CO LTD (JP) 2026-03-19 US disclosed
US-6150425-A COMPRISING AN OUTER PHASE OIL AND OIL IN WATER EMULSION IN THE INNER PHASE WHICH CONTAINING WATER, AN OIL BASED INGREDIENT, A SURFACTANT AND AN AMPHIPHILIC SUBSTANCE; PREPARED BY A HIGH PRESSURE OR ULTRASONIC EMULSIFICATION SHISEIDO COMPANY, LTD. (JP) 2000-11-21 US disclosed
WO-2000057840-A2 DERMATOLOGICAL TOPICAL COMPOSITION PENTAPHARM AG (CH) 2000-10-05 WO disclosed
EP-1002515-A1 SKIN COMPOSITIONS FOR EXTERNAL USE SHISEIDO COMPANY LIMITED (JP) 2000-05-24 EP disclosed
EP-0970741-A1 O/W/O TYPE MULTIPHASE EMULSION SHISEIDO COMPANY LIMITED (JP) 2000-01-12 EP disclosed
EP-0887070-A1 External composition for skin comprising sphingoglycolipid Kibun Food ChemiFA Co., Ltd. (JP) 1998-12-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078211-A1 A SOLID PARTICLE OF ORGANOSILICON-FUNCTIONAL CO-POLYMER, MANUFACTURING PROCESS THEREOF, AND COSMETICS COMPRISING SAID SOLID PARTICLE FOXM1, FOXK1, TAF1L THRB 4408/4885ATM 361/4885MAPT 2752/4885
US-12589062-B2 Powdery solid cosmetic preparation TMEM63A, CUTA, VCL THRB 690/4885ATM 214/4885MAPT 2757/4885
US-20100047185-A1 ACTVIE SUBSTANCE COMBINATION UGT2B17, TACR2, UGT1A1 THRB 1148/4885ATM 567/4885MAPT 922/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.