Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.59 |
| ▸ | RXRA | P19793 | 5/20 | 0.59 |
| ▸ | RARA | P10276 | 4/20 | 0.59 |
| ▸ | RARB | P10826 | 4/20 | 0.59 |
| ▸ | RARG | P13631 | 4/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | BLM | P54132 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.59 |
| ▸ | RXRB | P28702 | 2/20 | 0.59 |
| ▸ | RXRG | P48443 | 2/20 | 0.59 |
| ▸ | RORC | P51449 | 2/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isotretinoin Anisatil SCHEMBL14161050 | 1.00 | RBP4 (0.59) | RBP4ALDH1A1MAPTCYP3A4RXRA | |
| Isotretinoin Anisatil SCHEMBL8597493 | 1.00 | RBP4 (0.59) | RBP4ALDH1A1MAPTCYP3A4RXRA | |
| Isotretinoin Anisatil SCHEMBL4784232 | 1.00 | RBP4 (0.59) | RBP4ALDH1A1MAPTCYP3A4RXRA | |
| Isotretinoin Anisatil SCHEMBL8567772 | 1.00 | RBP4 (0.59) | RBP4ALDH1A1MAPTCYP3A4RXRA | |
| SCHEMBL8984781 | 0.93 | ALDH1A1 (0.59) | RBP4ALDH1A1MAPTCYP3A4RXRA | |
| SCHEMBL8984722 | 0.92 | ALDH1A1 (0.64) | RBP4ALDH1A1MAPTCYP3A4RXRA | |
| SCHEMBL8984755 | 0.92 | RBP4 (0.61) | RBP4ALDH1A1MAPTCYP3A4RXRA | |
| SCHEMBL8984824 | 0.91 | ALDH1A1 (0.65) | RBP4ALDH1A1MAPTCYP3A4RXRA | |
| SCHEMBL8984703 | 0.90 | ALDH1A1 (0.60) | RBP4ALDH1A1MAPTCYP3A4RXRA | |
| SCHEMBL342372 | 0.90 | ALDH1A1 (0.65) | RBP4ALDH1A1MAPTCYP3A4RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150005266-A1 | TOPICAL COMPOSITIONS FOR TREATMENT OF SKIN CONDITIONS | MOLECULAR DESIGN INTERNATIONAL, INC. | 2015-01-01 | — | — | US | claimed |
| US-8912175-B1 | Topical compositions for treatment of skin conditions | MOLECULAR DESIGN INTERNATIONAL, INC. (US) | 2014-12-16 | — | — | US | claimed |
| US-8865694-B2 | Topical compositions for treatment of skin conditions | MOLECULAR DESIGN INTERNATIONAL, INC. (US) | 2014-10-21 | — | — | US | claimed |
| US-20140066414-A2 | TOPICAL COMPOSITIONS FOR TREATMENT OF SKIN CONDITIONS | MOLECULAR DESIGN INTERNATIONAL, INC. | 2014-03-06 | — | — | US | claimed |
| US-20130237505-A1 | TOPICAL COMPOSITIONS FOR TREATMENT OF SKIN CONDITIONS | CONCERT, LLC (US) | 2013-09-12 | — | — | US | claimed |
| US-20080139518-A1 | Synergistic effect attributable to combination of a retinoid component and a salicylic acid component; combination of the two active ingredients provided a greater overall anti-acne effect than a treatment comprising benzoyl peroxide | CONCERT, LLC | 2008-06-12 | — | — | US | claimed |
| EP-0448636-A1 | DERMAL USES OF NON-IRRITATING RETINOIDS | MOLECULAR DESIGN INTERNATIONAL, INC. (US) | 1991-10-02 | — | — | EP | claimed |
| US-5049584-A | Dermal uses of cis-retinoids for the treatment of cancer | MOLECULAR DESIGN INTERNATIONAL (US) | 1991-09-17 | — | — | US | claimed |
| WO-1990006751-A1 | DERMAL USES OF NON-IRRITATING RETINOIDS | MOLECULAR DESIGN INTERNATIONAL, INC. (US) | 1990-06-28 | — | — | WO | claimed |
| US-20150005266-A1 | TOPICAL COMPOSITIONS FOR TREATMENT OF SKIN CONDITIONS | MOLECULAR DESIGN INTERNATIONAL, INC. | 2015-01-01 | — | — | US | disclosed |
| US-8912175-B1 | Topical compositions for treatment of skin conditions | MOLECULAR DESIGN INTERNATIONAL, INC. (US) | 2014-12-16 | — | — | US | disclosed |
| US-8865694-B2 | Topical compositions for treatment of skin conditions | MOLECULAR DESIGN INTERNATIONAL, INC. (US) | 2014-10-21 | — | — | US | disclosed |
| US-20140066414-A2 | TOPICAL COMPOSITIONS FOR TREATMENT OF SKIN CONDITIONS | MOLECULAR DESIGN INTERNATIONAL, INC. | 2014-03-06 | — | — | US | disclosed |
| US-20130237505-A1 | TOPICAL COMPOSITIONS FOR TREATMENT OF SKIN CONDITIONS | CONCERT, LLC (US) | 2013-09-12 | — | — | US | disclosed |
| US-5124356-A | Topical application of esters and amides of retinoic acid | MOLECULAR DESIGN INTERNATIONAL, INC. (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0448636-A4 | DERMAL USES OF NON-IRRITATING RETINOIDS | MOLECULAR DESIGN INT (US) | 1992-01-22 | — | — | EP | disclosed |
| EP-0448636-A1 | DERMAL USES OF NON-IRRITATING RETINOIDS | MOLECULAR DESIGN INTERNATIONAL, INC. (US) | 1991-10-02 | — | — | EP | disclosed |
| US-5049584-A | Dermal uses of cis-retinoids for the treatment of cancer | MOLECULAR DESIGN INTERNATIONAL (US) | 1991-09-17 | — | — | US | disclosed |
| US-4994491-A | Esters and amides of 13-cis and 13-trans retinoic acid | MOLECULAR DESIGN INTERNATIONAL (US) | 1991-02-19 | — | — | US | disclosed |
| WO-1990006751-A1 | DERMAL USES OF NON-IRRITATING RETINOIDS | MOLECULAR DESIGN INTERNATIONAL, INC. (US) | 1990-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005266-A1 | TOPICAL COMPOSITIONS FOR TREATMENT OF SKIN CONDITIONS | RARA, RARB, CUTA | RBP4 13/4885ALDH1A1 281/4885MAPT 3408/4885 |
| US-20130237505-A1 | TOPICAL COMPOSITIONS FOR TREATMENT OF SKIN CONDITIONS | RARA, RARB, CUTA | RBP4 13/4885ALDH1A1 281/4885MAPT 3408/4885 |
| US-20140066414-A2 | TOPICAL COMPOSITIONS FOR TREATMENT OF SKIN CONDITIONS | RARA, RARB, CUTA | RBP4 13/4885ALDH1A1 281/4885MAPT 3408/4885 |
| US-20080139518-A1 | Synergistic effect attributable to combination of a retinoid component and a salicylic acid component; combination of the two active ingredients provided a greater overall anti-acne effect than a treatment comprising benzoyl peroxide | RARA, RARB, CHUK | RBP4 30/4885ALDH1A1 165/4885MAPT 4791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.