Sugi Predict

Sugi Predict / Compounds / SCHEMBL4905979

SCHEMBL4905979

SCHEMBL4905979

Cc1ccc(S(=O)(=O)NCCc2ccc(OCc3ccccc3)cc2)cc1C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.57
▸ MEN1 O00255 1/20 0.55
▸ PKM P14618 1/20 0.55
▸ KMT2A Q03164 1/20 0.55
▸ TBXA2R P21731 1/20 0.55
▸ TBXAS1 P24557 1/20 0.55
▸ ALDH1A1 P00352 2/20 0.53
▸ POLB P06746 1/20 0.53
▸ SGMS1 Q86VZ5 3/20 0.53
▸ AKR1C3 P42330 3/20 0.53
▸ TP53 P04637 1/20 0.52
▸ ADAMTS4 O75173 1/20 0.51
▸ MMP1 P03956 1/20 0.51
▸ MMP2 P08253 1/20 0.51
▸ MMP9 P14780 1/20 0.51
▸ MMP13 P45452 1/20 0.51
▸ MMP14 P50281 1/20 0.51
▸ ADAM17 P78536 1/20 0.51
▸ ADAMTS5 Q9UNA0 1/20 0.51
▸ SFRP1 Q8N474 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4895348 0.94 AKR1C3 (0.55) LMNAMEN1PKMKMT2ATBXA2R
SCHEMBL4905124 0.93 ALDH1A1 (0.55) LMNAMEN1KMT2ATBXA2RTBXAS1
SCHEMBL4897468 0.92 ALDH1A1 (0.55) LMNAKMT2ATBXA2RTBXAS1ALDH1A1
SCHEMBL4907013 0.92 AKR1C3 (0.53) LMNAMEN1KMT2ATBXA2RTBXAS1
SCHEMBL4895584 0.91 LMNA (0.51) LMNAMEN1PKMKMT2ATBXA2R
SCHEMBL4895501 0.91 LMNA (0.58) LMNAMEN1PKMKMT2AALDH1A1
SCHEMBL4905297 0.89 ADAMTS4 (0.50) LMNAMEN1PKMKMT2ATBXA2R
SCHEMBL4904177 0.89 MMP2 (0.53) LMNAMEN1PKMKMT2ATBXA2R
SCHEMBL4902642 0.88 LMNA (0.60) LMNATBXA2RTBXAS1ALDH1A1POLB
SCHEMBL4903412 0.88 LMNA (0.52) LMNAMEN1KMT2ATBXA2RTBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD LMNA 317/4885MEN1 4859/4885PKM 896/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD LMNA 319/4885MEN1 4855/4885PKM 861/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD LMNA 319/4885MEN1 4855/4885PKM 861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.