Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29501701 | 0.82 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1HTR2A | |
| SCHEMBL9281778 | 0.79 | SIGMAR1 (0.51) | SIGMAR1MEN1KMT2AHTR2A | |
| SCHEMBL7673834 | 0.78 | KDM1A (0.45) | — | |
| SCHEMBL8095544 | 0.78 | MEN1 (0.30) | MEN1KMT2A | |
| SCHEMBL3219869 | 0.75 | SIGMAR1 (0.35) | SIGMAR1PRCPHTR2A | |
| Phenol SCHEMBL9774501 | 0.74 | ESR2 (0.40) | SIGMAR1ALDH1A1 | |
| SCHEMBL4899561 | 0.73 | — | — | |
| SCHEMBL8524367 | 0.72 | KDM1A (0.33) | ALDH1A1 | |
| SCHEMBL4899566 | 0.72 | GABRA1 (0.32) | — | |
| SCHEMBL3214158 | 0.69 | HTR2A (0.33) | SIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324970-B1 | RETINOIDS FOR THE TREATMENT OF EMPHYSEMA | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |