SCHEMBL490728

SCHEMBL490728

c1ccc(C2=NC(c3cccnc3)(C3(c4cccnc4)N=C(c4ccccc4)C(c4ccccc4)=N3)N=C2c2ccccc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 4/20 0.45
ALDH1A1 P00352 4/20 0.45
CYP3A4 P08684 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP19A1 P11511 3/20 0.41
BACE1 P56817 4/20 0.40
KDM4E B2RXH2 3/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
TP53 P04637 2/20 0.39
HPGD P15428 2/20 0.39
HSD17B10 Q99714 2/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
ALOX15 P16050 1/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 3/20 0.38
NPC1 O15118 2/20 0.38
NPY5R Q15761 1/20 0.38
CYP11B1 P15538 2/20 0.37
CYP11B2 P19099 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL491053 0.82 ALDH1A1 (0.39) ALDH1A1BACE1SMN1; SMN2LMNAALOX15
SCHEMBL490735 0.78 ALDH1A1 (0.41) ALDH1A1CYP3A4CYP1A2SMN1; SMN2HSD17B10
SCHEMBL8664748 0.69 CYP1A2 (0.48) ALDH1A1CYP1A2BACE1KDM4ESMN1; SMN2
SCHEMBL5554839 0.69 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2RAB9ANPC1CYP11B1
SCHEMBL14973574 0.69 NPC1 (0.41) ALDH1A1KDM4ESMN1; SMN2HPGDLMNA
SCHEMBL490744 0.69 NPY5R (0.44) ALDH1A1CYP19A1KDM4ESMN1; SMN2LMNA
SCHEMBL491016 0.69 BACE1 (0.41) BACE1
SCHEMBL16405704 0.68 CYP2A6 (0.83) CYP2A6ALDH1A1CYP3A4CYP1A2CYP19A1
SCHEMBL29500136 0.68 CYP2A6 (0.83) CYP2A6ALDH1A1CYP3A4CYP1A2CYP19A1
SCHEMBL141605 0.68 CYP2A6 (0.83) CYP2A6ALDH1A1CYP3A4CYP1A2CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8652759-B2 Processing of lithographic printing plates with a developer solution containing a hydrophilic polymer EASTMAN KODAK COMPANY (US) 2014-02-18 US disclosed
US-8632937-B2 UV-sensitive lithographic printing plate precursor with benzoxazole derivative and analogues thereof as sensitizer EASTMAN KODAK COMPANY (US) 2014-01-21 US disclosed
EP-1849600-B1 Bakeable radiation-sensitive elements with a high resistance to chemicals EASTMAN KODAK CO (US) 2013-12-11 EP disclosed
US-8507181-B2 Method for developing and sealing of lithographic printing plates KODAK (NEAR EAST) INC. 2013-08-13 US disclosed
US-8361701-B2 Method for making lithographic plates EASTMAN KODAK COMPANY (US) 2013-01-29 US disclosed
EP-2293144-B1 Method of drying lithographic printing plates after single-step-processing EASTMAN KODAK CO (US) 2012-11-07 EP disclosed
US-20120152139-A1 METHOD AND APPARATUS FOR DRYING AFTER SINGLE-STEP-PROCESSING OF LITHOGRAPHIC PRINTING PLATES QUALEX INC. 2012-06-21 US disclosed
US-8137891-B2 Bakeable lithographic printing plates with a high resistance to chemicals EASTMAN KODAK COMPANY (US) 2012-03-20 US disclosed
US-8119331-B2 Photopolymer composition usable for lithographic plates KODAK GRAPHIC COMMUNICATIONS GMBH (DE) 2012-02-21 US disclosed
US-8105755-B2 Method for processing of photopolymer printing plates with overcoat EASTMAN KODAK COMPANY (US) 2012-01-31 US disclosed
US-20070142490-A1 Radiation-sensitive compositions and imageable elements based thereon BAUMANN HARALD 2007-06-21 US disclosed
WO-2007009580-A2 PHOTOPOLYMER COMPOSITION SUITABLE FOR LITHOGRAPHIC PRINTING PLATES EASTMAN KODAK COMPANY (US) 2007-01-25 WO disclosed
EP-1690138-A1 RADIATION-SENSITIVE COMPOSITIONS AND IMAGEABLE ELEMENTS BASED THEREON Kodak Polychrome Graphics GmbH (DE) 2006-08-16 EP disclosed
US-20060154169-A1 Radiation-sensitive compositions comprising a 1,4-dihydropyridine sensitizer and imageable elements based thereon KODAK POLYCHROME GRAPHICS GMBH (DE) 2006-07-13 US disclosed
US-20060063101-A1 Radiation-sensitive elements KODAK POLYCHROME GRAPHICS LLC (US) 2006-03-23 US disclosed
EP-1586006-A1 RADIATION-SENSITIVE ELEMENTS Kodak Polychrome Graphics GmbH (DE) 2005-10-19 EP disclosed
WO-2005054952-A1 RADIATION-SENSITIVE COMPOSITIONS AND IMAGEABLE ELEMENTS BASED THEREON KODAK POLYCHROME GRAPHICS GMBH (DE) 2005-06-16 WO disclosed
WO-2004111731-A1 RADIATION-SENSITIVE COMPOSITIONS COMPRISING A 1,4-DIHYDROPYRIDINE SENSITIZER AND IMAGEABLE ELEMENTS BASED THEREON KODAK POLYCHROME GRAPHICS GMBH (DE) 2004-12-23 WO disclosed
WO-2004049068-A1 RADIATION-SENSITIVE ELEMENTS KODAK POLYCHROME GRAPHICS GMBH (DE) 2004-06-10 WO disclosed
US-4017313-A Photosensitive composition containing a leuco dye, a photosensitizer, an aromatic aldehyde and a secondary or tertiary amine and the use thereof in a direct-print process E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-04-12 US disclosed