SCHEMBL491053

SCHEMBL491053

c1ccc(C2=NC(c3ccccc3)(C3(c4ccccc4)N=C(c4ccccc4)C(c4ccccc4)=N3)N=C2c2ccccc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
RAB9A P51151 4/20 0.36
NPC1 O15118 3/20 0.36
MAPK1 P28482 1/20 0.36
NPY5R Q15761 1/20 0.35
KMT2A Q03164 4/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
TSHR P16473 1/20 0.35
NOTUM Q6P988 1/20 0.35
MEN1 O00255 2/20 0.33
IDO1 P14902 1/20 0.33
HTT P42858 1/20 0.33
BACE1 P56817 1/20 0.32
BACE2 Q9Y5Z0 1/20 0.32
LMNA P02545 1/20 0.32
GLA P06280 1/20 0.32
THRB P10828 1/20 0.32
CYP2C9 P11712 1/20 0.32
BLM P54132 1/20 0.32
PMP22 Q01453 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL490735 0.95 ALDH1A1 (0.41) ALDH1A1RAB9ANPC1MAPK1NPY5R
SCHEMBL490734 0.91 ALDH1A1 (0.41) ALDH1A1MAPK1TSHRNOTUMATM
SCHEMBL8664748 0.85 CYP1A2 (0.48) ALDH1A1RAB9ANPC1SMN1; SMN2TSHR
SCHEMBL5554839 0.85 ALDH1A1 (0.48) ALDH1A1RAB9ANPC1MAPK1SMN1; SMN2
SCHEMBL14973574 0.85 NPC1 (0.41) ALDH1A1RAB9ANPC1KMT2ASMN1; SMN2
SCHEMBL490744 0.85 NPY5R (0.44) ALDH1A1NPC1NPY5RKMT2ASMN1; SMN2
SCHEMBL8664728 0.83 CYP1A2 (0.52) ALDH1A1RAB9ANPC1KMT2ASMN1; SMN2
SCHEMBL11594968 0.83 ALDH1A1 (0.34) ALDH1A1RAB9ANPC1SMN1; SMN2TSHR
SCHEMBL490728 0.82 CYP2A6 (0.45) ALDH1A1RAB9ANPC1NPY5RSMN1; SMN2
SCHEMBL11595707 0.80 KDM4E (0.46) ALDH1A1RAB9ANPC1BACE1BACE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4271260-A POSITIVE IMAGES OBTAINED USING A SUPPORTED LAYER OF AN ALKALI-SOLUBLE POLYMERIC BINDER, A HEXAARYLBIIMIAZOLE, AND A CARBOXY-, CARBONYL-, OR CYANO-SUBSTITUTED DIHYDROPYRIDINE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-06-02 US claimed
JP-9208611-A None JP disclosed
US-8652759-B2 Processing of lithographic printing plates with a developer solution containing a hydrophilic polymer EASTMAN KODAK COMPANY (US) 2014-02-18 US disclosed
US-8632937-B2 UV-sensitive lithographic printing plate precursor with benzoxazole derivative and analogues thereof as sensitizer EASTMAN KODAK COMPANY (US) 2014-01-21 US disclosed
EP-1849600-B1 Bakeable radiation-sensitive elements with a high resistance to chemicals EASTMAN KODAK CO (US) 2013-12-11 EP disclosed
US-8507181-B2 Method for developing and sealing of lithographic printing plates KODAK (NEAR EAST) INC. 2013-08-13 US disclosed
US-8361701-B2 Method for making lithographic plates EASTMAN KODAK COMPANY (US) 2013-01-29 US disclosed
EP-2293144-B1 Method of drying lithographic printing plates after single-step-processing EASTMAN KODAK CO (US) 2012-11-07 EP disclosed
US-20120152139-A1 METHOD AND APPARATUS FOR DRYING AFTER SINGLE-STEP-PROCESSING OF LITHOGRAPHIC PRINTING PLATES QUALEX INC. 2012-06-21 US disclosed
US-8137891-B2 Bakeable lithographic printing plates with a high resistance to chemicals EASTMAN KODAK COMPANY (US) 2012-03-20 US disclosed
US-4698293-A Process for forming positive tonable images using a photosensitive material containing at least 1,4-dihydropyridine E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-10-06 US disclosed
EP-0224137-A2 Process for forming positive tonable images using a photosensitive material containing at least one 1,4-dihydropyridine E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-06-03 EP disclosed
US-4332884-A USING A DIOXIME CHELATING AGENT RICOH CO., LTD. (JP) 1982-06-01 US disclosed
US-4315068-A CONTAINING A COBALT-AMMINE COMPLEX AND A DIOXIME OR A BISIMIDAZOLIN-3-ONE CHELATING AGENT; STABILITY; COLOR DILMS RICOH CO., LTD. (JP) 1982-02-09 US disclosed
US-4306014-A AMMONIA OR AMINES SUPPRESS THE COLOR-FORMING REACTION SYSTEM RICOH CO., LTD. (JP) 1981-12-15 US disclosed
US-4292394-A Process for preparing multicolor toned images on a single photosensitive layer E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-09-29 US disclosed
US-4275140-A HAVING TACKY AREAS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-06-23 US disclosed
US-4264710-A AN ETHYLENICALLY UNSATURATED COMPOUND, AND A PHOTOPOLYMERIZATION INIATOR FUJI PHOTO FILM CO., LTD. (JP) 1981-04-28 US disclosed
US-4090877-A COLOR PHOTOGRAPHY MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1978-05-23 US disclosed
US-4017313-A Photosensitive composition containing a leuco dye, a photosensitizer, an aromatic aldehyde and a secondary or tertiary amine and the use thereof in a direct-print process E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-04-12 US disclosed