Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.50 |
| ▸ | FEN1 | P39748 | 2/20 | 0.50 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.50 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.50 |
| ▸ | TNKS | O95271 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 3/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19665231 | 0.79 | HPGD (0.53) | GAAMAPTTNKSPARP1TNKS2 | |
| SCHEMBL26387375 | 0.78 | MAPT (0.50) | GAAMAPTERCC1FEN1ERCC4 | |
| SCHEMBL26395120 | 0.73 | PIN1 (0.56) | GAAMAPTERCC1FEN1ERCC4 | |
| SCHEMBL5381545 | 0.73 | CDC7 (0.59) | GAAMAPTHPGDALDH1A1GSK3B | |
| SCHEMBL5384453 | 0.70 | CYP19A1 (0.59) | GAAMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5390769 | 0.70 | NPY5R (0.53) | GAAMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL10927029 | 0.68 | SCN2A (0.61) | PIN1 | |
| SCHEMBL547250 | 0.68 | GAA (0.48) | GAAMAPTERCC1FEN1ERCC4 | |
| SCHEMBL17348563 | 0.68 | TNKS (0.66) | MAPTERCC1FEN1ERCC4RNASEH1 | |
| SCHEMBL4822785 | 0.68 | GSK3B (0.84) | GAAMAPTHPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089051-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES: PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |
| US-20080171756-A1 | N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171756-A1 | N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | GAA 172/4885MAPT 4781/4885ERCC1 2651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.