Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL970746 | 0.94 | LMNA (0.43) | LMNABLMPTGS1PDE4ASLC6A6 | |
| Propane SCHEMBL28339028 | 0.94 | LMNA (0.43) | LMNABLMPTGS1PDE4ASLC6A6 | |
| Methyl Alcohol SCHEMBL28253720 | 0.90 | — | — | |
| SCHEMBL827 | 0.90 | — | — | |
| SCHEMBL249947 | 0.90 | LMNA (0.50) | LMNABLMPTGS1PDE4ASLC6A6 | |
| SCHEMBL28031140 | 0.88 | LMNA (0.39) | LMNABLMPTGS1PDE4ASLC6A6 | |
| SCHEMBL18155126 | 0.88 | LMNA (0.43) | LMNABLMPTGS1PDE4ASLC6A6 | |
| SCHEMBL19814012 | 0.88 | — | — | |
| SCHEMBL1138506 | 0.87 | — | — | |
| SCHEMBL1177405 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706476-B1 | NOVEL ACYLALKYLISETHIONATE ESTERS AND APPLICATIONS IN CONSUMER PRODUCTS | HUNTSMAN PETROCHEMICAL LLC (US) | 2018-01-10 | — | — | EP | disclosed |
| US-9598358-B2 | Acylalkylisethionate esters and applications in consumer products | HUNTSMAN PETROCHEMICAL LLC (US) | 2017-03-21 | — | — | US | disclosed |
| CN-1906288-B | Novel acyl alkyl isethionates and use in consumer products | HUNTSMAN PETROCHEMICAL CORP. (US) | 2016-01-06 | — | — | CN | disclosed |
| US-8580723-B2 | Process compositions and production of acyl alkylisethionate compositions | HUNTSMAN PETROCHEMICAL LLC (US) | 2013-11-12 | — | — | US | disclosed |
| EP-2021445-B1 | PROCESS COMPOSITIONS AND PRODUCTION OF ACYL ALKYLISETHIONATE COMPOSITIONS | HUNTSMAN PETROCHEMICAL LLC (US) | 2013-10-02 | — | — | EP | disclosed |
| CN-103315919-A | Novel acylalkylisethionate esters and applications in consumer products | HUNTSMAN SPEC CHEM CORP | 2013-09-25 | — | — | CN | disclosed |
| US-20120094890-A1 | Process Compositions and Production of Acyl Alkylisethionate Compositions | HUNTSMAN PETROCHEMICAL LLC (US) | 2012-04-19 | — | — | US | disclosed |
| US-8105993-B2 | Process compositions and production of acyl alkylisethionate compositions | HUNTSMAN PETROCHEMICAL LLC (US) | 2012-01-31 | — | — | US | disclosed |
| US-20110257072-A1 | NOVEL ACYLALKYLISETHIONATE ESTERS AND APPLICATIONS IN CONSUMER PRODUCTS | INDORAMA VENTURES OXIDES LLC | 2011-10-20 | — | — | US | disclosed |
| US-8008239-B2 | reacting bisulfites with alkylene oxides to form alkyl-substituted hydroxyalkyl sulfonates, which react with carboxylic acids under esterification conditions to form acylalkylisethionate esters, used as cleaning compounds | HUNTSMAN PETROCHEMICAL LLC (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100215610-A1 | PROCESS COMPOSITIONS AND PRODUCTION OF ACYL ALKYLISETHIONATE COMPOSITIONS | HUNTSMAN PETROCHEMICAL CORPORATION (US) | 2010-08-26 | — | — | US | disclosed |
| EP-2021445-A2 | PROCESS COMPOSITIONS AND PRODUCTION OF ACYL ALKYLISETHIONATE COMPOSITIONS | Huntsman Petrochemical Corporation (US) | 2009-02-11 | — | — | EP | disclosed |
| US-20080234159-A1 | Novel Acylalkylisethionate Esters and Applications in Consumer Products | HUNTSMAN PETROCHEMICAL CORPORATION (US) | 2008-09-25 | — | — | US | disclosed |
| WO-2007130390-A2 | PROCESS COMPOSITIONS AND PRODUCTION OF ACYL ALKYLISETHIONATE COMPOSITIONS | HUNTSMAN PETROCHEMICAL CORPORATION (US) | 2007-11-15 | — | — | WO | disclosed |
| CN-1906288-A | Novel acyl alkyl isethionates and use in consumer products | HUNTSMAN SPEC CHEM CORP (US) | 2007-01-31 | — | — | CN | disclosed |
| EP-1706476-A1 | NOVEL ACYLALKYLISETHIONATE ESTERS AND APPLICATIONS IN CONSUMER PRODUCTS | HUNTSMAN PETROCHEMICAL CORPORATION (US) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005075623-A1 | NOVEL ACYLALKYLISETHIONATE ESTERS AND APPLICATIONS IN CONSUMER PRODUCTS | HUNTSMAN PETROCHEMICAL CORPORATION (US) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257072-A1 | NOVEL ACYLALKYLISETHIONATE ESTERS AND APPLICATIONS IN CONSUMER PRODUCTS | AGPAT5, AGPAT2, TST | LMNA 4508/4885BLM 4409/4885PTGS1 1584/4885 |
| US-20100215610-A1 | PROCESS COMPOSITIONS AND PRODUCTION OF ACYL ALKYLISETHIONATE COMPOSITIONS | FADS1, ABHD5, AGPAT5 | LMNA 3464/4885BLM 4734/4885PTGS1 1975/4885 |
| US-20080234159-A1 | Novel Acylalkylisethionate Esters and Applications in Consumer Products | ABHD5, AGPAT5, FADS1 | LMNA 3839/4885BLM 4435/4885PTGS1 1793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.