Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | RHEB | Q15382 | 2/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 2/20 | 0.33 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4899169 | 0.85 | DDB1 (0.35) | DDB1CRBNCES2CES1GRM5 | |
| SCHEMBL24952543 | 0.82 | GRM5 (0.42) | DDB1CRBNCYP3A4TSHRCES2 | |
| SCHEMBL4908472 | 0.79 | DDB1 (0.33) | DDB1CRBNCES2CES1NFE2L2 | |
| SCHEMBL4912458 | 0.79 | FBP1 (0.33) | DDB1CRBNTSHRCES2CES1 | |
| SCHEMBL645965 | 0.78 | ALDH1A1 (0.38) | DDB1CRBNHSD17B10TSHRCES2 | |
| SCHEMBL19121400 | 0.78 | DDB1 (0.37) | DDB1CRBNCES2CES1GRM5 | |
| SCHEMBL16404705 | 0.78 | CES2 (0.41) | DDB1CRBNCES2CES1GRM5 | |
| SCHEMBL4126762 | 0.78 | DDB1 (0.37) | DDB1CRBNCES2CES1GRM5 | |
| SCHEMBL4908432 | 0.78 | DDB1 (0.37) | DDB1CRBNCES2CES1GRM5 | |
| SCHEMBL4904139 | 0.76 | DDB1 (0.31) | DDB1CRBNRHEBSMN1; SMN2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9949480-B2 | N-alkylthio beta-lactams, alkyl-coenzyme A asymmetric disulfides, and aryl-alkyl disulfides as anti-bacterial agents | UNIVERSITY OF SOUTH FLORIDA (US) | 2018-04-24 | — | — | US | disclosed |
| US-20150327547-A1 | N-ALKYLTHIO BETA-LACTAMS, ALKYL-COENZYME A ASYMMETRIC DISULFIDES, AND ARYL-ALKYL DISULFIDES AS ANTI-BACTERIAL AGENTS | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-11-19 | — | — | US | disclosed |
| US-9096635-B2 | N-alkylthio beta-lactams, alkyl-coenzyme A asymmetric disulfides, and aryl-alkyl disulfides as anti-bacterial agents | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140235565-A1 | N-ALKYLTHIO BETA-LACTAMS, ALKYL-COENZYME A ASYMMETRIC DISULFIDES, AND ARYL-ALKYL DISULFIDES AS ANTI-BACTERIAL AGENTS | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-08-21 | — | — | US | disclosed |
| US-8722937-B2 | Asymmetric disulfides and aryl-alkyl disulfides as anti-bacterial agents | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-05-13 | — | — | US | disclosed |
| US-20080182815-A1 | Act against several infective agents, and most notably Bacillus spp. and Staphylococcus spp., including infection caused by methicillin-resistant Staphylococcus aureus (MRSA) | UNIVERSITY OF SOUTH FLORIDA | 2008-07-31 | — | — | US | disclosed |
| US-4238611-A | Polysubstituted derivatives of 10-piperazinodibenzo (b,f) thiepine | SPOFA, UNITED PHARMACEUTICAL WORKS (CS) | 1980-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182815-A1 | Act against several infective agents, and most notably Bacillus spp. and Staphylococcus spp., including infection caused by methicillin-resistant Staphylococcus aureus (MRSA) | SQOR, TST, COASY | DDB1 2877/4885CRBN 3829/4885HSD17B10 156/4885 |
| US-20150327547-A1 | N-ALKYLTHIO BETA-LACTAMS, ALKYL-COENZYME A ASYMMETRIC DISULFIDES, AND ARYL-ALKYL DISULFIDES AS ANTI-BACTERIAL AGENTS | COASY, SQOR, TST | DDB1 1708/4885CRBN 2135/4885HSD17B10 160/4885 |
| US-20140235565-A1 | N-ALKYLTHIO BETA-LACTAMS, ALKYL-COENZYME A ASYMMETRIC DISULFIDES, AND ARYL-ALKYL DISULFIDES AS ANTI-BACTERIAL AGENTS | COASY, SQOR, TST | DDB1 1708/4885CRBN 2135/4885HSD17B10 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.