Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 7/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CDC42 | P60953 | 1/20 | 0.49 |
| ▸ | RAC1 | P63000 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15675337 | 1.00 | AKR1C3 (0.50) | AKR1C3AKR1C2MAPTMAPK1PTGS2 | |
| SCHEMBL27894547 | 0.86 | MAPT (0.51) | MAPTMAPK1KDM4EALDH1A1HTR1A | |
| SCHEMBL3675315 | 0.85 | AKR1C3 (0.51) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL490989 | 0.85 | PKM (0.55) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL2930054 | 0.83 | MAPT (0.49) | MAPTMAPK1TSHRKDM4EALDH1A1 | |
| SCHEMBL5740611 | 0.83 | MAPT (0.49) | MAPTMAPK1KDM4EALDH1A1HTR1A | |
| SCHEMBL31103530 | 0.81 | PTGS2 (0.53) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL1572868 | 0.81 | BLM (0.62) | MAPTMAPK1TSHRKDM4EALDH1A1 | |
| SCHEMBL1572866 | 0.81 | BLM (0.62) | MAPTMAPK1TSHRKDM4EALDH1A1 | |
| SCHEMBL3669295 | 0.81 | AKR1C3 (0.51) | AKR1C3AKR1C2MAPTMAPK1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1556786-A | 3,4,5-trimethoxy phenyl-based ester compound and preparation method thereof and whitening cosmetic composition containing the same | ��ʽ����̫ƽ�� | 2004-12-22 | — | — | CN | claimed |
| CN-111973586-A | Application of 4-aryl coumarin compound | 山东省医学科学院药物研究所（山东省抗衰老研究中心、山东省新技术制药研究所） | 2020-11-24 | — | — | CN | disclosed |
| CN-104974221-B | Dipeptide and tripeptide proteasome inhibitors and preparation method and pharmaceutical application thereof | 中国医学科学院药物研究所 | 2020-10-23 | — | — | CN | disclosed |
| CN-106187904-A | 2-phenylimidazole analog derivative containing propioloyl amido and preparation method thereof and pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2016-12-07 | — | — | CN | disclosed |
| US-8889876-B2 | Histone deacetylase inhibitors and uses thereof | JIANGSU HENGYI PHARMACEUTICAL CO., LTD. (CN) | 2014-11-18 | — | — | US | disclosed |
| US-20140135520-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER | Tokyo University of Science Educational Foundation Administration Organization (JP) | 2014-05-15 | — | — | US | disclosed |
| CN-103342729-A | Caffeoyl substituted pentacyclic triterpenoid derivatives and purpose thereof | SHANGHAI INST MATERIA MEDICA | 2013-10-09 | — | — | CN | disclosed |
| US-8268293-B2 | Using compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, such as 4-hydroxyphenylpropionic acid, or 2-ethylhexyl 4-hydroxy-3,5-dimethoxycinnamate, or polysiloxanes which contain benzylidenemalonic acid derivatives | MERCK PATENT GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| CN-101163659-B | Antioxidants | MERCK PATENT GMBH | 2012-09-05 | — | — | CN | disclosed |
| CN-101633638-B | Class I histone deacetylase inhibitor and application thereof | JIANGSU GOWORTH INVEST CO LTD | 2012-07-25 | — | — | CN | disclosed |
| US-6972296-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-12-06 | — | — | US | disclosed |
| CN-1556786-A | 3,4,5-trimethoxy phenyl-based ester compound and preparation method thereof and whitening cosmetic composition containing the same | ��ʽ����̫ƽ�� | 2004-12-22 | — | — | CN | disclosed |
| CN-1412181-A | Carboxylic acid derivatives inhibiting the binding of integrins to their receptors | TEXAS BIOTECHNOLOGIES CORP (US) | 2003-04-23 | — | — | CN | disclosed |
| CN-1401621-A | Intermediate for preparing tricyclic compound and preparation method of intermediate | HOECHST MARION ROUSSEL INC (FR) | 2003-03-12 | — | — | CN | disclosed |
| CN-1090178-C | Tricyclic compounds having activity specific for integrins, in particular alpha v beta 3 integrins, process and intermediates for their preparation, their use as medicaments and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2002-09-04 | — | — | CN | disclosed |
| CN-1360498-A | Carboxylic acid derivs. that inhibit binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORP (US) | 2002-07-24 | — | — | CN | disclosed |
| CN-1310171-A | Novel tricyclic derivatives and process for their preparation | ROUSSEL UCLAF (FR) | 2001-08-29 | — | — | CN | disclosed |
| CN-1219165-A | Tricyclic compounds having activity specific for integrins, in particular alpha v beta 3 integrins, process and intermediates for their preparation, their use as medicaments and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL CO (FR) | 1999-06-09 | — | — | CN | disclosed |
| CN-1143622-A | Novel tricyclic derivatives, their preparation, their use and intermediates | ROUSSEL UCLAF (FR) | 1997-02-26 | — | — | CN | disclosed |
| US-3936462-A | CNS DEPRESSANT, ANALGESIC | STERLING DRUG INC. (US) | 1976-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135520-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER | ALDH1A2, ADH1C, ADH1A | AKR1C3 130/4885AKR1C2 242/4885MAPT 1725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.