Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.54 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.48 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.46 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.46 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 6/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.59 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.59 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL23672238 | 1.00 | ESR1 (0.59) | ESR1ESR2PDCD1CD274ADRB2 | |
| Bromide SCHEMBL15901678 | 1.00 | ESR1 (0.59) | ESR1ESR2PDCD1CD274ADRB2 | |
| SCHEMBL633374 | 0.97 | ESR1 (0.62) | ESR1ESR2PDCD1CD274ADRB2 | |
| SCHEMBL2032476 | 0.97 | ESR1 (0.62) | ESR1ESR2PDCD1CD274ADRB2 | |
| SCHEMBL2037513 | 0.97 | ESR1 (0.62) | ESR1ESR2PDCD1CD274ADRB2 | |
| Hydrochloric Acid SCHEMBL14830851 | 0.95 | ESR1 (0.59) | ESR1ESR2PDCD1CD274ADRB2 | |
| Hydrochloric Acid SCHEMBL8702706 | 0.95 | ESR1 (0.59) | ESR1ESR2PDCD1CD274ADRB2 | |
| Hydrochloric Acid SCHEMBL3178913 | 0.95 | ESR1 (0.59) | ESR1ESR2PDCD1CD274ADRB2 | |
| Iodide SCHEMBL29068279 | 0.95 | ESR1 (0.59) | ESR1ESR2PDCD1CD274ADRB2 | |
| SCHEMBL18664397 | 0.90 | ESR1 (0.54) | ESR1ESR2PDCD1CD274ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080009534-A1 | SUBSTITUTED ACID DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009534-A1 | SUBSTITUTED ACID DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD | GPR119, LIPC, CEL | ADRB2 877/4885SLC6A2 2081/4885CHRM2 1494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.