Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CCR2 | P41597 | 2/20 | 0.46 |
| ▸ | CCR4 | P51679 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4910505 | 0.82 | CCR2 (0.48) | ALDH1A1TDP1KMT2AMEN1CCR2 | |
| SCHEMBL4637188 | 0.82 | TDP1 (0.58) | ALDH1A1SMN1; SMN2TDP1KMT2AMEN1 | |
| SCHEMBL17047599 | 0.81 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2TDP1KMT2AMEN1 | |
| SCHEMBL4912893 | 0.81 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2TDP1KMT2AMEN1 | |
| SCHEMBL4907248 | 0.81 | L3MBTL1 (0.51) | ALDH1A1TDP1KMT2AMEN1CCR2 | |
| SCHEMBL4907252 | 0.81 | TSHR (0.51) | ALDH1A1SMN1; SMN2KMT2AMEN1CYP3A4 | |
| SCHEMBL4907245 | 0.81 | TSHR (0.51) | ALDH1A1SMN1; SMN2KMT2AMEN1CYP3A4 | |
| SCHEMBL4913347 | 0.80 | MAPT (0.56) | ALDH1A1SMN1; SMN2TDP1KMT2AMEN1 | |
| SCHEMBL1367920 | 0.80 | TDP1 (0.58) | ALDH1A1SMN1; SMN2TDP1KMT2AMEN1 | |
| SCHEMBL8075212 | 0.79 | TDP1 (0.51) | ALDH1A1SMN1; SMN2TDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345899-B1 | BENZOFURAN-2-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3345899-B1 | BENZOFURAN-2-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3345899-A1 | BENZOFURAN-2-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | Allergan, Inc. (US) | 2018-07-11 | — | — | EP | disclosed |
| EP-3345899-A1 | BENZOFURAN-2-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | Allergan, Inc. (US) | 2018-07-11 | — | — | EP | disclosed |
| EP-2820010-B1 | BENZOFURAN-2-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2018-05-09 | — | — | EP | disclosed |
| EP-2820010-B1 | BENZOFURAN-2-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2018-05-09 | — | — | EP | disclosed |
| US-9416120-B2 | Benzofuran-2-sulfonamides pyridine derivatives as chemokine receptor modulators | ALLERGAN, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-9416120-B2 | Benzofuran-2-sulfonamides pyridine derivatives as chemokine receptor modulators | ALLERGAN, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-9416120-B2 | Benzofuran-2-sulfonamides pyridine derivatives as chemokine receptor modulators | ALLERGAN, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| EP-2820010-A1 | BENZOFURAN- 2 - SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2015-01-07 | — | — | EP | disclosed |
| WO-2013130962-A1 | BENZOFURAN- 2 - SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2013-09-06 | — | — | WO | disclosed |
| US-20130231339-A1 | BENZOFURAN-2-SULFONAMIDES PYRIDINE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130231339-A1 | BENZOFURAN-2-SULFONAMIDES PYRIDINE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130231339-A1 | BENZOFURAN-2-SULFONAMIDES PYRIDINE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-20080293720-A1 | Pyridinyl Sulfonamide Modulators of Chemokine Receptors | GLAXO GROUP LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| US-20080293720-A1 | Pyridinyl Sulfonamide Modulators of Chemokine Receptors | GLAXO GROUP LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| US-20080293720-A1 | Pyridinyl Sulfonamide Modulators of Chemokine Receptors | GLAXO GROUP LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| EP-1962847-A2 | PYRIDINYL SULFONAMIDE MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067875-A2 | PYRIDINYL SULFONAMIDE MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMTED (GB) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007067875-A2 | PYRIDINYL SULFONAMIDE MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMTED (GB) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231339-A1 | BENZOFURAN-2-SULFONAMIDES PYRIDINE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | CCR2, CXCR2, CXCR4 | ALDH1A1 2064/4885SMN1; SMN2 3781/4885TDP1 4737/4885 |
| US-20080293720-A1 | Pyridinyl Sulfonamide Modulators of Chemokine Receptors | CCR2, CCR1, CCRL2 | ALDH1A1 1334/4885SMN1; SMN2 2031/4885TDP1 4723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.