SCHEMBL491020

SCHEMBL491020

COc1ccc(C2=NC(c3ccc(Cl)cc3)(C3(c4ccc(Cl)cc4)N=C(c4ccc(OC)cc4)C(c4ccc(OC)cc4)=N3)N=C2c2ccc(OC)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
HPGD P15428 2/20 0.42
ALOX5 P09917 2/20 0.42
ALDH1A1 P00352 2/20 0.42
GLA P06280 1/20 0.42
GSK3B P49841 1/20 0.40
CLK4 Q9HAZ1 1/20 0.40
MAPT P10636 2/20 0.40
EDNRA P25101 1/20 0.40
MEN1 O00255 1/20 0.40
CYP2C9 P11712 1/20 0.40
AGTR1 P30556 1/20 0.40
CYP2C19 P33261 1/20 0.40
KMT2A Q03164 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PIK3CA P42336 1/20 0.40
PIK3CB P42338 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8664760 0.85 NPC1 (0.49) NPC1RAB9AALDH1A1CLK4MAPT
SCHEMBL11595707 0.83 KDM4E (0.46) NPC1RAB9AHPGDALDH1A1CLK4
SCHEMBL150156 0.83 ALDH1A1 (0.46) NPC1RAB9AALDH1A1MAPTNPSR1
SCHEMBL491080 0.80 GSK3B (0.45) ALDH1A1GSK3BMAPTMEN1KMT2A
SCHEMBL8664728 0.79 CYP1A2 (0.52) SMN1; SMN2NPC1RAB9AALDH1A1MEN1
SCHEMBL11278246 0.78 ALDH1A1 (0.45) SMN1; SMN2NPC1RAB9AHPGDALDH1A1
SCHEMBL7538061 0.77 KMT2A (0.38) SMN1; SMN2NPC1RAB9AHPGDALDH1A1
SCHEMBL8664748 0.77 CYP1A2 (0.48) SMN1; SMN2NPC1RAB9AHPGDALDH1A1
SCHEMBL3947663 0.75 HPGD (0.59) SMN1; SMN2NPC1RAB9AHPGDALOX5
SCHEMBL490794 0.74 RELA (0.40) SMN1; SMN2NPC1RAB9AALDH1A1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8652759-B2 Processing of lithographic printing plates with a developer solution containing a hydrophilic polymer EASTMAN KODAK COMPANY (US) 2014-02-18 US disclosed
US-8632937-B2 UV-sensitive lithographic printing plate precursor with benzoxazole derivative and analogues thereof as sensitizer EASTMAN KODAK COMPANY (US) 2014-01-21 US disclosed
EP-1849600-B1 Bakeable radiation-sensitive elements with a high resistance to chemicals EASTMAN KODAK CO (US) 2013-12-11 EP disclosed
US-8507181-B2 Method for developing and sealing of lithographic printing plates KODAK (NEAR EAST) INC. 2013-08-13 US disclosed
US-8361701-B2 Method for making lithographic plates EASTMAN KODAK COMPANY (US) 2013-01-29 US disclosed
US-20120152139-A1 METHOD AND APPARATUS FOR DRYING AFTER SINGLE-STEP-PROCESSING OF LITHOGRAPHIC PRINTING PLATES QUALEX INC. 2012-06-21 US disclosed
US-8137891-B2 Bakeable lithographic printing plates with a high resistance to chemicals EASTMAN KODAK COMPANY (US) 2012-03-20 US disclosed
US-8119331-B2 Photopolymer composition usable for lithographic plates KODAK GRAPHIC COMMUNICATIONS GMBH (DE) 2012-02-21 US disclosed
US-8105755-B2 Method for processing of photopolymer printing plates with overcoat EASTMAN KODAK COMPANY (US) 2012-01-31 US disclosed
US-8034538-B2 Negative-working imageable elements EASTMAN KODAK COMPANY (US) 2011-10-11 US disclosed
EP-0999473-A1 Photosensitive resin composition and photosensitive element using the same HITACHI CHEMICAL COMPANY, LTD. (JP) 2000-05-10 EP disclosed
US-6060216-A USING AS AN ETHYLENICALLY UNSATURATED COMPOUND A COMPOUND IN WHICH AN ISOCYANURATE RING AND AN ACRYLATE (OR METHACRYLATE) ARE BONDED BY A FLEXIBLE ALKYLENE OXIDE GROUP (SUCH AS POLYETHYLENE OR POLYPROPYLENE OXIDE AND AN ALKYLENE GROUP HITACHI CHEMICAL CO., LTD. (JP) 2000-05-09 US disclosed
US-6004725-A IMPROVED ADHESION AND RESOLUTION, NEGATIVE ACTING, ACRYLATE FUNCTIONAL ISOCYANATE TRIMER MORTON INTERNATIONAL, INC. (US) 1999-12-21 US disclosed
EP-0962827-A2 Photoimageable composition having improved photoinitiator system Nichigo-Morton Co Ltd (JP) 1999-12-08 EP disclosed
US-5939238-A Photoimageable composition having improved photoinitiator system MORTON INTERNATIONAL, INC. (US) 1999-08-17 US disclosed
EP-0927911-A2 Photoimageable compositions containing photopolymerizable urethane oligomers Nichigo-Morton Co Ltd (JP) 1999-07-07 EP disclosed
EP-0919870-A1 Photosensitive resin composition and photosensitive element using the resin composition Nichigo-Morton Co Ltd (JP) 1999-06-02 EP disclosed
US-5744282-A CONSISTS OF AN ACRYLIC BINDER POLYMER, ATLEAST ONE PHOTOPOLYMERIZABLE COMPOUND HAVING A POLYMERIZABLE DOUBLE BOND, A PHOTOINITIATOR AND A DICYANDIAMIDE; PHOTOSENSITIVITY, ADHESIION, FLEXIBILITY, PLATING/AND CHEMICAL RESISTANCE HITACHI CHEMICAL CO., LTD. (JP) 1998-04-28 US disclosed
EP-0738927-A2 Photosensitive resin composition and photosensitive element using the same HITACHI CHEMICAL COMPANY, LTD. (JP) 1996-10-23 EP disclosed
US-4264710-A AN ETHYLENICALLY UNSATURATED COMPOUND, AND A PHOTOPOLYMERIZATION INIATOR FUJI PHOTO FILM CO., LTD. (JP) 1981-04-28 US disclosed