SCHEMBL8664728

SCHEMBL8664728

Clc1ccc(C2=NC(c3ccc(Cl)cc3)(C3(c4ccc(Cl)cc4)N=C(c4ccccc4)C(c4ccc(Cl)cc4)=N3)N=C2c2ccccc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.52
GAA P10253 2/20 0.44
KDM4E B2RXH2 1/20 0.44
LMNA P02545 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
NR1H2 P55055 2/20 0.39
NR1H3 Q13133 2/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
SCN2A Q99250 1/20 0.39
RECQL P46063 1/20 0.39
HSD11B1 P28845 2/20 0.38
NR1I2 O75469 1/20 0.38
TSHR P16473 1/20 0.37
CTRC Q99895 1/20 0.37
MECP2 P51608 1/20 0.37
MBD2 Q9UBB5 1/20 0.37
MAP4K4 O95819 1/20 0.37
CTSD P07339 1/20 0.36
BACE1 P56817 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8664748 0.98 CYP1A2 (0.48) CYP1A2GAAKDM4ELMNAL3MBTL1
SCHEMBL490735 0.84 ALDH1A1 (0.41) CYP1A2NPC1RAB9ATSHRALDH1A1
SCHEMBL491053 0.83 ALDH1A1 (0.39) LMNANPC1RAB9ATSHRBACE1
SCHEMBL7538061 0.83 KMT2A (0.38) GAALMNANPC1RAB9ARECQL
SCHEMBL5554839 0.78 ALDH1A1 (0.48) NR1H2NR1H3NPC1RAB9AMAP4K4
SCHEMBL14973574 0.78 NPC1 (0.41) KDM4ELMNAL3MBTL1NR1H2NR1H3
SCHEMBL490744 0.78 NPY5R (0.44) GAAKDM4ELMNAL3MBTL1NPC1
SCHEMBL8664760 0.77 NPC1 (0.49) KDM4ELMNAL3MBTL1NPC1RAB9A
SCHEMBL2519476 0.76 MAOA (0.37) LMNAALDH1A1SMN1; SMN2
SCHEMBL491288 0.76 CYP1A2 (0.40) CYP1A2GAAKDM4ELMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5792589-A ORGANIC BINDER; OPTICALLY CROSSLINKABLE COMPOUND; RADICAL-GENERATING AGENT: 2,4,5-TRIARYL IMIDAZOLE DIMER, AMINO-GROUP CONTAINING BENZOPHENONE PHOTOSENSITIZER, A THIOL COMPOUND JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1998-08-11 US disclosed