SCHEMBL491080

SCHEMBL491080

COc1ccc(C2=NC(c3ccc(C#N)cc3)(C3(c4ccc(C#N)cc4)N=C(c4ccc(OC)cc4)C(c4ccc(OC)cc4)=N3)N=C2c2ccc(OC)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.45
MAPKAPK2 P49137 1/20 0.44
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
THRB P10828 1/20 0.42
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
CYP19A1 P11511 2/20 0.40
ADORA1 P30542 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
STAT3 P40763 2/20 0.40
CYP1A1 P04798 1/20 0.40
CYP1B1 Q16678 1/20 0.40
ACP1 P24666 1/20 0.39
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 1/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8664760 0.81 NPC1 (0.49) KDM4EALDH1A1MAPT
SCHEMBL491020 0.80 SMN1; SMN2 (0.45) GSK3BMEN1KMT2AALDH1A1MAPT
SCHEMBL150156 0.79 ALDH1A1 (0.46) KDM4EALDH1A1MAPT
SCHEMBL11595707 0.79 KDM4E (0.46) KDM4EALDH1A1MAPT
SCHEMBL91929 0.78 MAOA (0.56) GSK3BMAPKAPK2MEN1KMT2ATHRB
SCHEMBL3419967 0.78 MAOA (0.56) GSK3BMAPKAPK2MEN1KMT2ATHRB
SCHEMBL103904 0.76 MAOB (0.61) GSK3BMAPKAPK2MEN1KMT2AMAOA
SCHEMBL30757515 0.76 MAOB (0.61) GSK3BMAPKAPK2MEN1KMT2AMAOA
1,4-Dimethoxybenzene SCHEMBL28617696 0.76 MAOB (0.61) GSK3BMAPKAPK2MEN1KMT2AMAOA
SCHEMBL20282381 0.75 MAOA (0.53) GSK3BMAPKAPK2MEN1KMT2ATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8652759-B2 Processing of lithographic printing plates with a developer solution containing a hydrophilic polymer EASTMAN KODAK COMPANY (US) 2014-02-18 US disclosed
US-8632937-B2 UV-sensitive lithographic printing plate precursor with benzoxazole derivative and analogues thereof as sensitizer EASTMAN KODAK COMPANY (US) 2014-01-21 US disclosed
EP-1849600-B1 Bakeable radiation-sensitive elements with a high resistance to chemicals EASTMAN KODAK CO (US) 2013-12-11 EP disclosed
US-8361701-B2 Method for making lithographic plates EASTMAN KODAK COMPANY (US) 2013-01-29 US disclosed
EP-2293144-B1 Method of drying lithographic printing plates after single-step-processing EASTMAN KODAK CO (US) 2012-11-07 EP disclosed
US-8119331-B2 Photopolymer composition usable for lithographic plates KODAK GRAPHIC COMMUNICATIONS GMBH (DE) 2012-02-21 US disclosed
US-8105755-B2 Method for processing of photopolymer printing plates with overcoat EASTMAN KODAK COMPANY (US) 2012-01-31 US disclosed
EP-2396173-A1 NEGATIVE-WORKING IMAGEABLE ELEMENTS Eastman Kodak Company (US) 2011-12-21 EP disclosed
US-8034538-B2 Negative-working imageable elements EASTMAN KODAK COMPANY (US) 2011-10-11 US disclosed
US-20110223540-A1 GUMMING COMPOSITIONS WITH NANO-PARTICLES FOR IMPROVING SCRATCH SENSITIVITY IN IMAGE AND NON-IMAGE AREAS OF LITHOGRAPHIC PRINTING PLATES EASTMAN KODAK COMPANY 2011-09-15 US disclosed
US-20060154169-A1 Radiation-sensitive compositions comprising a 1,4-dihydropyridine sensitizer and imageable elements based thereon KODAK POLYCHROME GRAPHICS GMBH (DE) 2006-07-13 US disclosed
US-20060063101-A1 Radiation-sensitive elements KODAK POLYCHROME GRAPHICS LLC (US) 2006-03-23 US disclosed
EP-1586006-A1 RADIATION-SENSITIVE ELEMENTS Kodak Polychrome Graphics GmbH (DE) 2005-10-19 EP disclosed
WO-2005054952-A1 RADIATION-SENSITIVE COMPOSITIONS AND IMAGEABLE ELEMENTS BASED THEREON KODAK POLYCHROME GRAPHICS GMBH (DE) 2005-06-16 WO disclosed
WO-2004111731-A1 RADIATION-SENSITIVE COMPOSITIONS COMPRISING A 1,4-DIHYDROPYRIDINE SENSITIZER AND IMAGEABLE ELEMENTS BASED THEREON KODAK POLYCHROME GRAPHICS GMBH (DE) 2004-12-23 WO disclosed
WO-2004049068-A1 RADIATION-SENSITIVE ELEMENTS KODAK POLYCHROME GRAPHICS GMBH (DE) 2004-06-10 WO disclosed
US-4332884-A USING A DIOXIME CHELATING AGENT RICOH CO., LTD. (JP) 1982-06-01 US disclosed
US-4315068-A CONTAINING A COBALT-AMMINE COMPLEX AND A DIOXIME OR A BISIMIDAZOLIN-3-ONE CHELATING AGENT; STABILITY; COLOR DILMS RICOH CO., LTD. (JP) 1982-02-09 US disclosed
US-4306014-A AMMONIA OR AMINES SUPPRESS THE COLOR-FORMING REACTION SYSTEM RICOH CO., LTD. (JP) 1981-12-15 US disclosed
US-4017313-A Photosensitive composition containing a leuco dye, a photosensitizer, an aromatic aldehyde and a secondary or tertiary amine and the use thereof in a direct-print process E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-04-12 US disclosed