Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.66 |
| ▸ | CDK8 | P49336 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.49 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903360 | 0.90 | FERMT2 (0.55) | CCNCCDK8HTR1AADRA1DADRA1A | |
| SCHEMBL2990471 | 0.83 | FERMT2 (0.65) | CCNCCDK8HTR1AADRA1DADRA1A | |
| SCHEMBL15483266 | 0.83 | CCNC (0.54) | CCNCCDK8HTR1AADRA1DADRA1A | |
| SCHEMBL4912004 | 0.82 | ALDH1A1 (0.45) | CCNCCDK8ALDH1A1NPSR1KMT2A | |
| SCHEMBL21750432 | 0.80 | CCNC (1.00) | CCNCCDK8HTR1AADRA1DADRA1A | |
| SCHEMBL2621805 | 0.78 | CCNC (0.62) | CCNCCDK8HTR1AADRA1DADRA1A | |
| SCHEMBL1219722 | 0.77 | CYP2C19 (0.51) | ALDH1A1NPSR1MAPTPOLBHTT | |
| SCHEMBL26640796 | 0.75 | MAPT (0.58) | ALDH1A1NPSR1KMT2AMAPTL3MBTL1 | |
| SCHEMBL1594797 | 0.75 | ALDH1A1 (0.72) | ALDH1A1NPSR1KMT2AMAPTKDM4E | |
| SCHEMBL4913166 | 0.74 | HTR1A (0.73) | HTR1AADRA1DADRA1AADRA1BFERMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2008-02-21 | — | — | US | disclosed |
| US-6992089-B2 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE UNIVERSITY OF NEW JERSEY (US) | 2006-01-31 | — | — | US | disclosed |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | CCNC 247/4885CDK8 439/4885HTR1A 2567/4885 |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | CCNC 532/4885CDK8 671/4885HTR1A 1558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.