SCHEMBL491319

SCHEMBL491319

O=S(=O)(CF)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSIP1 O75475 1/20 0.61
APOBEC3G Q9HC16 1/20 0.52
HTR6 P50406 1/20 0.50
HSD11B1 P28845 6/20 0.47
ALDH1A1 P00352 3/20 0.46
HSD17B10 Q99714 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA3 P07451 1/20 0.46
CA4 P22748 1/20 0.46
CA6 P23280 1/20 0.46
CA5A P35218 1/20 0.46
CA7 P43166 1/20 0.46
PLA2G7 Q13093 1/20 0.46
CA9 Q16790 1/20 0.46
CA13 Q8N1Q1 1/20 0.46
CA14 Q9ULX7 1/20 0.46
CA5B Q9Y2D0 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1748405 0.82 CA1 (0.48) PSIP1APOBEC3GHTR6ALDH1A1HSD17B10
SCHEMBL778246 0.80 PSIP1 (0.56) PSIP1APOBEC3GHTR6HSD11B1ALDH1A1
SCHEMBL777601 0.78 PSIP1 (0.67) PSIP1HTR6HSD11B1ALDH1A1HSD17B10
SCHEMBL64761 0.78 PSIP1 (0.67) PSIP1HTR6HSD11B1ALDH1A1HSD17B10
SCHEMBL15199478 0.77 MMP2 (0.46) HSD11B1ALDH1A1HSD17B10CA1CA2
SCHEMBL1546083 0.77 PSIP1 (0.52) PSIP1HTR6HSD11B1ALDH1A1CA2
SCHEMBL180713 0.76 PSIP1 (1.00) PSIP1HTR6HSD11B1ALDH1A1HSD17B10
SCHEMBL3329009 0.76 PSIP1 (0.64) PSIP1HTR6HSD11B1ALDH1A1HSD17B10
SCHEMBL2646690 0.76 PLCG1 (0.44) PSIP1HTR6HSD11B1CA12CA1
SCHEMBL10437234 0.75 CA2 (0.57) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 313 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113493386-A Novel high-selectivity asymmetric synthesis process of 2-fluorocyclopropylamine 北京桦冠生物技术有限公司 2021-10-12 CN claimed
EP-0724566-A1 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-08-07 EP claimed
WO-1995011883-A1 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1995-05-04 WO claimed
US-20260116912-A1 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF SAGE THERAPEUTICS INC (US) 2026-04-30 US disclosed
US-20260116911-A1 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF SAGE THERAPEUTICS INC (US) 2026-04-30 US disclosed
EP-4717314-A2 3,3 DISUBSTITUTED 19-NOR PREGNANE COMPOUNDS, COMPOSITIONS, AND USES THEREOF Sage Therapeutics, LLC (US) 2026-04-01 EP disclosed
EP-3572417-B1 3,3 DISUBSTITUTED 19-NOR PREGNANE COMPOUNDS, COMPOSITIONS, AND USES THEREOF SAGE THERAPEUTICS LLC (US) 2025-12-17 EP disclosed
EP-4660199-A1 19-NOR NEUROACTIVE STEROIDS FOR INDUCING SEDATION Sage Therapeutics, Inc. (US) 2025-12-10 EP disclosed
CN-121064178-A Method for synthesizing ICLEPERTIN 济南诺博汀精细化工有限公司 2025-12-05 CN disclosed
EP-4640277-A2 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID FOR USE IN THERAPY Sage Therapeutics, Inc. (US) 2025-10-29 EP disclosed
US-20250319106-A1 19-NOR C3, 3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF SAGE THERAPEUTICS INC (US) 2025-10-16 US disclosed
EP-0365849-B1 Novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl adenosine derivatives MERRELL DOW PHARMA (US) 1994-09-14 EP disclosed
WO-1993023370-A1 PROCESS FOR THE PREPARATION OF FLUOROMETHYL THIO BENZENES MERRELL DOW PHARMACEUTICALS INC. (US) 1993-11-25 WO disclosed
CN-1022248-C Novel 2'-halomethylidene, uridine and guanosine drivatives MERRELL DOW PHARMA (US) 1993-09-29 CN disclosed
EP-0403559-A1 IMPROVEMENTS RELATING TO ANTIGENS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1990-12-27 EP disclosed
CN-1046334-A New 2 '-halogenated methylene, 2 '-vinylidene and 2 '-the ethynyl adenosine derivative MERRELL DOW PHARMA (US) 1990-10-24 CN disclosed
CN-1042715-A New 2 '-halogenated methylene, 2 '-vinylidene and 2 '-ethynyl cytidine, uridine and black glycoside derivates MERRELL DOW PHARMA (US) 1990-06-06 CN disclosed
EP-0365849-A2 Novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl adenosine derivatives MERRELL DOW PHARMACEUTICALS INC. (US) 1990-05-02 EP disclosed
EP-0336562-A1 Improvements relating to antigens CANCER RESEARCH CAMPAIGN TECHNOLOGY LTD. (GB) 1989-10-11 EP disclosed
WO-1989007947-A1 IMPROVEMENTS RELATING TO ANTIGENS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1989-09-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250319106-A1 19-NOR C3, 3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF NR3C2, NR3C1, CYP11B1 PSIP1 3270/4885APOBEC3G 3089/4885HTR6 547/4885
US-20260116912-A1 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF SCN4A, CHRNA4, CACNG4 PSIP1 1090/4885APOBEC3G 4344/4885HTR6 267/4885
US-20260116911-A1 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF SCN4A, CACNG4, SLC6A4 PSIP1 1006/4885APOBEC3G 4211/4885HTR6 237/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.