Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.72 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.72 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.50 |
| ▸ | CCR4 | P51679 | 1/20 | 0.50 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP10 | P09238 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5494002 | 0.99 | ADRB2 (0.74) | ADRB2ADRB1ADRB3RAB9AGAA | |
| SCHEMBL27812589 | 0.95 | ADRB2 (0.67) | ADRB2ADRB1ADRB3RAB9AGAA | |
| Bromide SCHEMBL27812101 | 0.94 | ADRB2 (0.65) | ADRB2ADRB1ADRB3RAB9AGAA | |
| SCHEMBL13181102 | 0.89 | ADRB2 (0.59) | ADRB2ADRB1ADRB3RAB9AGAA | |
| SCHEMBL13503715 | 0.83 | RAB9A (0.62) | ADRB2ADRB1ADRB3RAB9AGAA | |
| SCHEMBL206453 | 0.82 | ADRB3 (0.59) | ADRB2ADRB1ADRB3RAB9AGAA | |
| SCHEMBL28818145 | 0.81 | ALDH1A1 (0.59) | ADRB2ADRB1ADRB3RAB9AGAA | |
| SCHEMBL28007919 | 0.81 | ADRB2 (0.55) | ADRB2ADRB1ADRB3RAB9AGAA | |
| SCHEMBL9385942 | 0.80 | CSNK2A1 (0.58) | ADRB2ADRB1ADRB3RAB9AGAA | |
| SCHEMBL1527377 | 0.80 | GAA (0.61) | ADRB2ADRB1ADRB3RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820869-B1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT (HU) | 2023-08-30 | — | — | EP | disclosed |
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2021-10-28 | — | — | US | disclosed |
| EP-3820865-A1 | THIADIAZINE DERIVATIVES | Richter Gedeon Nyrt. (HU) | 2021-05-19 | — | — | EP | disclosed |
| EP-3820869-A1 | SPIROCHROMANE DERIVATIVES | Richter Gedeon Nyrt. (HU) | 2021-05-19 | — | — | EP | disclosed |
| WO-2020012423-A1 | THIADIAZINE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2020-01-16 | — | — | WO | disclosed |
| WO-2020012422-A1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2020-01-16 | — | — | WO | disclosed |
| WO-2020012424-A1 | SUBSTITUTED (AZA)INDOLE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2020-01-16 | — | — | WO | disclosed |
| EP-1926719-B1 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-31 | — | — | EP | disclosed |
| WO-2016154110-A1 | COMPANION DIAGNOSTIC FOR P97 INHIBITOR THERAPY AND METHODS OF USE THEREOF | CLEAVE BIOSCIENCES, INC. (US) | 2016-09-29 | — | — | WO | disclosed |
| US-9388175-B2 | 2-aniline-4-aryl substituted thiazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2016-07-12 | — | — | US | disclosed |
| US-20120157457-A1 | COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2012-06-21 | — | — | US | disclosed |
| US-8105581-B2 | Compositions and methods for inducing neuronal differentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-01-31 | — | — | US | disclosed |
| US-20110269748-A1 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-11-03 | — | — | US | disclosed |
| CN-101263130-B | 2-aniline-4-aryl substituted thiazole derivatives | JANSSEN PHARMACEUTICA NV | 2011-03-09 | — | — | CN | disclosed |
| US-20100166710-A1 | Compositions and Methods for Inducing Neuronal Differentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-07-01 | — | — | US | disclosed |
| EP-1968597-A1 | COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION | The Scripps Research Institute (US) | 2008-09-17 | — | — | EP | disclosed |
| CN-101263130-A | 2-aniline-4-aryl substituted thiazole derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2008-09-10 | — | — | CN | disclosed |
| EP-1926719-A2 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007064891-A1 | COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-06-07 | — | — | WO | disclosed |
| WO-2007031440-A2 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269748-A1 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | CHRNA4, CHRNA5, CHRNA7 | ADRB2 105/4885ADRB1 92/4885ADRB3 94/4885 |
| US-20100166710-A1 | Compositions and Methods for Inducing Neuronal Differentiation | CHAT, DCX, GAP43 | ADRB2 3641/4885ADRB1 3919/4885ADRB3 3050/4885 |
| US-20120157457-A1 | COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION | CHAT, DCX, GAP43 | ADRB2 3641/4885ADRB1 3919/4885ADRB3 3050/4885 |
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | CHRNA7, CHRM3, ADRB3 | ADRB2 13/4885ADRB1 5/4885ADRB3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.