Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5459307 | 1.00 | ALDH1A1 (0.36) | ALDH1A1PDE4APDE7A | |
| SCHEMBL4127530 | 1.00 | ALDH1A1 (0.36) | ALDH1A1PDE4APDE7A | |
| SCHEMBL1611506 | 0.98 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL842418 | 0.93 | — | — | |
| SCHEMBL8848675 | 0.89 | — | — | |
| SCHEMBL5612040 | 0.89 | — | — | |
| SCHEMBL5612049 | 0.89 | — | — | |
| SCHEMBL16099095 | 0.82 | — | — | |
| SCHEMBL2420244 | 0.80 | — | — | |
| SCHEMBL26410062 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976340-B1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-06-13 | — | — | EP | disclosed |
| US-9725445-B2 | Cycloalkyl nitrile pyrazolo pyridones as Janus kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-08 | — | — | US | disclosed |
| US-9725445-B2 | Cycloalkyl nitrile pyrazolo pyridones as Janus kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-08 | — | — | US | disclosed |
| US-20160280704-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-09-29 | — | — | US | disclosed |
| US-20160280704-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-09-29 | — | — | US | disclosed |
| EP-2976340-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-01-27 | — | — | EP | disclosed |
| WO-2014146490-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014146490-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-09-25 | — | — | WO | disclosed |
| US-20140073651-A1 | BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2014-03-13 | — | — | US | disclosed |
| EP-2678317-A1 | BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012114268-A1 | BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-08-30 | — | — | WO | disclosed |
| US-8106073-B2 | Quinoline derivatives 057 | ASTRAZENECA AB (SE) | 2012-01-31 | — | — | US | disclosed |
| EP-2225222-B1 | A QUINOLINE DERIVATIVE ACTING AS A P2X7-RECEPTOR ANTAGONIST | ASTRAZENECA AB (SE) | 2011-09-14 | — | — | EP | disclosed |
| EP-2225222-A1 | A QUINOLINE DERIVATIVE ACTING AS A P2X7-RECEPTOR ANTAGONIST | AstraZeneca AB (SE) | 2010-09-08 | — | — | EP | disclosed |
| US-20090143428-A1 | Quinoline Derivatives 057 | ASTRAZENECA AB (SE) | 2009-06-04 | — | — | US | disclosed |
| WO-2009070116-A1 | A QUINOLINE DERIVATIVE ACTING AS A P2X7-RECEPTOR ANTAGONIST | ASTRAZENECA AB (SE) | 2009-06-04 | — | — | WO | disclosed |
| US-20080146612-A1 | Novel Biaromatic Compounds, Inhibitors of the P2X7-Receptor | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | US | disclosed |
| EP-1844003-A1 | NOVEL BIAROMATIC COMPOUNDS, INHIBITORS OF THE P2X7-RECEPTOR | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006080884-A1 | NOVEL BIAROMATIC COMPOUNDS, INHIBITORS OF THE P2X7-RECEPTOR | ASTRAZENECA AB (SE) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146612-A1 | Novel Biaromatic Compounds, Inhibitors of the P2X7-Receptor | P2RX2, P2RX1, ADORA1 | ALDH1A1 719/4885PDE4A 1047/4885PDE7A 777/4885 |
| US-20090143428-A1 | Quinoline Derivatives 057 | CYP3A7, UGT1A7, UGT2B7 | ALDH1A1 816/4885PDE4A 299/4885PDE7A 411/4885 |
| US-20140073651-A1 | BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | P2RX3, P2RX7, P2RX1 | ALDH1A1 1255/4885PDE4A 1049/4885PDE7A 1189/4885 |
| US-20160280704-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | JAK1, JAK3, JAK2 | ALDH1A1 1154/4885PDE4A 645/4885PDE7A 1147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.