Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491578 | 1.00 | ALDH1A1 (0.36) | ALDH1A1PDE4APDE7A | |
| SCHEMBL4127530 | 1.00 | ALDH1A1 (0.36) | ALDH1A1PDE4APDE7A | |
| SCHEMBL1611506 | 0.98 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL842418 | 0.93 | — | — | |
| SCHEMBL8848675 | 0.89 | — | — | |
| SCHEMBL5612040 | 0.89 | — | — | |
| SCHEMBL5612049 | 0.89 | — | — | |
| SCHEMBL16099095 | 0.82 | — | — | |
| SCHEMBL2420244 | 0.80 | — | — | |
| SCHEMBL26410062 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073651-A1 | BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2014-03-13 | — | — | US | disclosed |
| EP-2678317-A1 | BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2014-01-01 | — | — | EP | disclosed |
| CN-103391923-A | As P2X7Benzamide derivatives of receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2013-11-13 | — | — | CN | disclosed |
| WO-2012114268-A1 | BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-08-30 | — | — | WO | disclosed |
| US-20070134737-A1 | Fluorophore compounds and their use in biological systems | STANFORD UNIVERSITY (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070134737-A1 | Fluorophore compounds and their use in biological systems | STANFORD UNIVERSITY (US) | 2007-06-14 | — | — | US | disclosed |
| US-20050009109-A1 | FLUOROPHORE COMPOUNDS AND THEIR USE IN BIOLOGICAL SYSTEMS | STANFORD UNIVERSITY (US) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070134737-A1 | Fluorophore compounds and their use in biological systems | DHODH, DUT, DPYD | ALDH1A1 371/4885PDE4A 2762/4885PDE7A 1287/4885 |
| US-20140073651-A1 | BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | P2RX3, P2RX7, P2RX1 | ALDH1A1 1255/4885PDE4A 1049/4885PDE7A 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.